多发性硬化诊断和治疗中国专家共识(2018版)

被引:147
|
作者
邱伟
徐雁
机构
[1] 中国免疫学会神经免疫分会
[2] 中华医学会神经病学分会神经免疫学组
关键词
多发性硬化; 诊断:治疗; 共识;
D O I
暂无
中图分类号
R744.51 [];
学科分类号
摘要
<正>多发性硬化(multiple sclerosis,MS)是一种以中枢神经系统(CNS)炎性脱髓鞘病变为主要特点的免疫介导性疾病,病变主要累及白质。其病因尚不明确,可能与遗传、环境、病毒感染等多种因素相关。MS病理上表现为CNS多发髓鞘脱失,可伴有神经细胞及其轴索损伤,MRI上病灶分布、形态及信号表现具有一定特征性。MS病变具有时间多发(DIT)和空间多发(DIS)的特点[1-3]。1 MS的临床分型
引用
收藏
页码:387 / 394
页数:8
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  • [1] 干扰素β-1b治疗385例多发性硬化患者的回顾性研究
    徐雁
    黄德晖
    张星虎
    董会卿
    付锦
    檀国军
    张美妮
    王磊
    杨丽
    高枫
    候世芳
    金涛
    矫毓娟
    方乐
    刘广志
    张伟赫
    方方
    王苏平
    戚晓昆
    吴哲
    安中平
    郭守刚
    张晓君
    郭力
    吴卫平
    王维治
    许贤豪
    崔丽英
    [J]. 中华神经科杂志, 2015, 48 (09) : 781 - 785
  • [2] ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis
    Montalban, Xavier
    Gold, Ralf
    Thompson, Alan J.
    Otero-Romero, Susana
    Amato, Maria Pia
    Chandraratna, Dhia
    Clanet, Michel
    Comi, Giancarlo
    Derfuss, Tobias
    Fazekas, Franz
    Hartung, Hans Peter
    Havrdova, Eva
    Hemmer, Bernhard
    Kappos, Ludwig
    Liblau, Roland
    Lubetzki, Catherine
    Marcus, Elena
    Miller, David H.
    Olsson, Tomas
    Pilling, Steve
    Selmaj, Krysztof
    Siva, Axel
    Sorensen, Per Soelberg
    Sormani, Maria Pia
    Thalheim, Christoph
    Wiendl, Heinz
    Zipp, Frauke
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2018, 24 (02) : 96 - 120
  • [3] Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria[J] . Alan J Thompson,Brenda L Banwell,Frederik Barkhof,William M Carroll,Timothy Coetzee,Giancarlo Comi,Jorge Correale,Franz Fazekas,Massimo Filippi,Mark S Freedman,Kazuo Fujihara,Steven L Galetta,Hans Peter Hartung,Ludwig Kappos,Fred D Lublin,Ruth Ann Marrie,Aaron E Miller,David H Miller,Xavier Montalban,Ellen M Mowry,Per Soelberg Sorensen,Mar Tintoré,Anthony L Traboulsee,Maria Trojano,Bernard M J Uitdehaag,Sandra Vukusic,
  • [4] Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial[J] . Aaron E Miller,Jerry S Wolinsky,Ludwig Kappos,Giancarlo Comi,Mark S Freedman,Tomas P Olsson,Deborah Bauer,Myriam Benamor,Philippe Truffinet,Paul W O’Connor.Lancet Neurology . 2014 (10)
  • [5] Defining the clinical course of multiple sclerosis: The 2013 revisions[J] . Fred D. Lublin,Stephen C. Reingold,Jeffrey A. Cohen,Gary R. Cutter,Per Soelberg S?rensen,Alan J. Thompson,Jerry S. Wolinsky,Laura J. Balcer,Brenda Banwell,Frederik Barkhof,Bruce Bebo,Peter A. Calabresi,Michel Clanet,Giancarlo Comi,Robert J. Fox,Mark S. Freedman,Andrew D. Goodman,Matilde Inglese,Ludwig Kappos,Bernd C. Kieseier,John A. Lincoln,Catherine Lubetzki,Aaron E. Miller,Xavier Montalban,Paul W. O?Connor,John Petkau
  • [6] Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial[J] . Christian Confavreux,Paul O’Connor,Giancarlo Comi,Mark S Freedman,Aaron E Miller,Tomas P Olsson,Jerry S Wolinsky,Teresa Bagulho,Jean-Luc Delhay,Deborah Dukovic,Philippe Truffinet,Ludwig Kappos.Lancet Neurology . 2014 (3)
  • [7] Novel Immunomodulatory Approaches for the Management of Multiple Sclerosis
    Kantarci, O. H.
    Pirko, I.
    Rodriguez, M.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (01) : 32 - 44
  • [8] Consensus guidelines for the diagnosis and treatment of multiple sclerosis
    Yamout, B.
    Alroughani, R.
    Al-Jumah, M.
    Khoury, S.
    Abouzeid, N.
    Dahdaleh, M.
    Alsharoqi, I.
    Inshasi, J.
    Hashem, S.
    Zakaria, M.
    ElKallab, K.
    Alsaadi, T.
    Tawfeek, T.
    Bohlega, S.
    [J]. CURRENT MEDICAL RESEARCH AND OPINION, 2013, 29 (06) : 611 - 621
  • [9] Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
    Martinelli, V.
    Cocco, E.
    Capra, R.
    Salemi, G.
    Gallo, P.
    Capobianco, M.
    Pesci, I.
    Ghezzi, A.
    Pozzilli, C.
    Lugaresi, A.
    Bellantonio, P.
    Amato, M. P.
    Grimaldi, L. M.
    Trojano, M.
    Mancardi, G. L.
    Bergamaschi, R.
    Gasperini, C.
    Rodegher, M.
    Straffi, L.
    Ponzio, M.
    Comi, G.
    [J]. NEUROLOGY, 2011, 77 (21) : 1887 - 1895
  • [10] Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology[J] . Neurology . 2010 (18)