OVEREXPRESSION OF p53, EGFR,C-ERBB2 AND C-ERBB3 IN ENDOMETRIOIDCARCINOMA OF THE OVARY

被引：0
|
作者：
冷金花
郎景和
沈铿
郭丽娜
机构：
[1] Beijing 100730
[2] CAMS & PUMC
[3] Department of Obstetrics and Gynecology
[4] Peking Union Medical College Hospital
来源：
ChineseMedicalSciencesJournal | 1997年 / 02期
关键词：
endometrioid carcinoma; ovary; p53;
D O I：
暂无
中图分类号：
R737.31 [卵巢肿瘤];
学科分类号：
100214 ;
摘要：
Objectives. To determine overexpression of p53, EGFR, c-erbB-2 and c-erbB-3 in endometrioid carcinoma of the ovary and to evaluate the prognostic significance of these results, especially, coexisting overexpression of p53 and one of the member of type I growth factor receptor family.Methods. Overexpressions of the p53, EGFR, c-erbB-2 and c-erbB-3 protein were studied by im-munohistochemistry in paraffin-embedded tumor tissue from 28 patients with endometrioid carcinoma of the ovary.Results. 11 (39.3%), 13 (46. 4%), and 14 (50. 0%) were stained positively with p53, c-erbB-2 and c-erbB-3 monoclonal antibodies. 13 (46- 4%) was stained positively with EGFR polyclonal antibody. There were no relationship between p53, EGFR, C-erbB-2, c-erbB-3 and histologic grade, lymph node metastasis. The percentage of tumors with over expression of p53, EGFR, C-erbB-2 and c-erbB-3 was higher in those with stage Ⅱ-Ⅲ tumors compared with those with stage Ⅰ , in patients with residual tumor after initial surgery compared w
引用
收藏
页码：67 / 70
页数：4
相关论文
共 50 条
  • [1] Prognostic significance of the coexpression of p53 protein and c-erbB2 in breast cancer
    Tsutsui, S
    Ohno, S
    Murakami, S
    Kataoka, A
    Kinoshita, J
    Hachitanda, Y
    AMERICAN JOURNAL OF SURGERY, 2003, 185 (02) : 165 - 167
  • [2] Immunohistochemical expression of p53 and c-erbB2 proteins in breast cancer in Egypt
    Helal, TE
    Khalifa, A
    Kamel, AS
    ANTICANCER RESEARCH, 2000, 20 (3B) : 2145 - 2150
  • [3] Comparison of the immunohistochemical expression of EGFR, c-erbB2 and p53 protein between primary and recurrent breast cancer
    Tsutsui S.
    Ohno S.
    Murakami S.
    Kataoka A.
    Kinoshita J.
    Hachitanda Y.
    Breast Cancer, 2002, 9 (2) : 111 - 117
  • [4] c-erbB2 receptor and P53 protein expression in canine mammary gland carcinoma
    Rezaie A.
    Tavasoli A.
    Mehrazma M.
    Bahonar A.
    Comparative Clinical Pathology, 2012, 21 (6) : 1633 - 1636
  • [5] Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer
    Sanz-Ortega, J
    Steinberg, SM
    Moro, E
    Saez, M
    Lopez, JA
    Sierra, E
    Sanz-Esponera, J
    Merino, MJ
    HISTOLOGY AND HISTOPATHOLOGY, 2000, 15 (02) : 455 - 462
  • [6] EGFR, c-erbB2 and p53 protein in the primary lesions and paired metastatic regional lymph nodes in breast cancer
    Tsutsui, S
    Ohno, S
    Murakami, S
    Kataoka, A
    Kinoshita, J
    Hachitanda, Y
    EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2002, 28 (04): : 383 - 387
  • [7] C-erbB2 and p53 expression are not associated with stage progression of gastric cancer in Britain or Japan
    McCulloch, P
    Taggart, T
    Ochiai, A
    ODowd, G
    Nash, J
    Sasako, M
    EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1997, 23 (04): : 304 - 309
  • [8] Expression of c-erbB2 and p53 in Curatively Resected Gastric Cancer: Correlation with Clinicopathologic Features and Prognosis
    Hur, Hoon
    Yi, Jeong Min
    Lee, In Kyu
    Song, Kyo Young
    Kim, Wook
    Park, Cho Hyun
    Jeon, Hae Myung
    JOURNAL OF THE KOREAN SURGICAL SOCIETY, 2011, 80 (03): : 172 - 181
  • [9] Positive expression of p53, c-erbB2 and MRP proteins is correlated with survival rates of NSCLC patients
    Xu, Yujin
    Wang, Liancong
    Zheng, Xiao
    Liu, Guan
    Wang, Yuezhen
    Lai, Xiaojing
    Li, Jianqiang
    MOLECULAR AND CLINICAL ONCOLOGY, 2013, 1 (03) : 487 - 492
  • [10] EXPRESSION OF C-ERBB-2 AND P53 IN COLORECTAL ADENOCARCINOMA
    SUN, XF
    CARSTENSEN, JM
    NORDENSKJOLD, B
    ANALYTICAL CELLULAR PATHOLOGY, 1995, 8 (03): : 203 - 211
12345