Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

被引:37
作者
Yan-Lan Fang [1 ]
Hong Chen [2 ]
Chun-Lin Wang [1 ]
Li Liang [1 ]
机构
[1] Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University
[2] College of Medicine, Zhejiang University
关键词
Non-alcoholic steatohepatitis; Children; Adolescents; Pathogenesis; Nonalcoholic fatty liver disease;
D O I
暂无
中图分类号
R725.7 [小儿消化系及腹部疾病];
学科分类号
100202 ;
摘要
Nonalcoholic fatty liver disease(NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver-which generally follows a benign, non-progressive clinical course-to non-alcoholic steatohepatitis, a subset of NAFLD that may progress to cirrhosis and end-stage liver disease or liver carcinoma. The underlying pathophysiological mechanism of "pediatric" NAFLD remains unclear, although it is strongly associated with obesity and insulin resistance. In this review we provide a general overview on the current understanding of NAFLD in children and adolescents, which underpins practice, enabling early diagnosis and appropriate therapeutic intervention for this life-threatening liver disease.
引用
收藏
页码:2974 / 2983
页数:10
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