鼻咽癌患者血清miR-144-3p及miR-151-3p的表达水平及临床价值

被引：2

作者：

薛玉峰 ^{[1
]}

张会平 ^{[1
]}

王芳 ^{[2
]}

郝宗生 ^{[1
]}

机构：

[1] 涿州市医院耳鼻喉科

[2] 涿州市医院药剂科

来源：

现代检验医学杂志 | 2021年 / 36卷 / 05期

关键词：

鼻咽癌; 微小核糖核酸-144-3p; 微小核糖核酸-151-3p;

D O I：

暂无

中图分类号：

R739.63 [咽肿瘤];

学科分类号：

100214 ;

摘要：

目的探讨鼻咽癌患者血清miR-144-3p及miR-151-3p的表达水平及临床价值。方法选取2016年1月2020年7月涿州市医院收治的106例鼻咽癌患者和50例健康对照组作为研究对象,采用实时定量PCR法检测miR-144-3p及miR-151-3p表达水平。应用受试者工作特征（ROC）曲线分析miR-144-3p及miR-151-3p诊断鼻咽癌的价值。Pearson相关分析鼻咽癌患者血清miR-144-3p与miR-151-3p表达水平的相关性。结果鼻咽癌组血清miR-144-3p（2.36±1.05 vs 0.82±0.27）及miR-151-3p（3.58±1.73 vs 0.97±0.36）表达水平均明显高于对照组,差异有统计学意义（均P <0.001）。鼻咽癌患者血清miR-144-3p及miR-151-3p表达水平升高与临床分期高、分化程度低、淋巴结转移及远处转移有关（t=5.824～19.307,均P <0.01）。ROC曲线显示,miR-144-3p为1.61及miR-151-3p为2.25是诊断鼻咽癌的最佳截断值,二者联合诊断鼻咽癌的曲线下面积（0.937,95%CI:0.875～0.99）最大,其敏感度和特异度为95.3%和87.0%。鼻咽癌患者血清miR-144-3p表达水平与miR-151-3p呈正相关（r=0.872,P<0.001）。结论鼻咽癌患者血清miR-144-3p及miR-151-3表达水平明显升高,二者联合诊断鼻咽癌的价值较高。

引用

页码：65 / 68

页数：4

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