GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy

被引：0
|
作者：
YANG Yue [1 ]
LIAO Yan [1 ]
GUI Yan-Ping [1 ]
ZHAO Li [1 ]
GUO Lu-Bo [2 ]
机构：
[1] School of Basic Medicine and Clinical Pharmacology, China Pharmaceutical University
[2] Department of Pharmacy, Central Hospital Affiliated to Shandong First Medical University
来源：
ChineseJournalofNaturalMedicines | 2020年 / 18卷 / 07期
基金：
中国国家自然科学基金;
关键词：
GL-V9; Drug resistance; JNK2; Autophagy;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤];
学科分类号：
100214 ;
摘要：
Adriamycin resistance in HCC seriously hinders the treatment of patients, it is necessary to investigate the mechanisms.Autophagy is involved in adriamycin resistance and JNK2 is related to autophagy.However, whether JNK2 inducing drug resistance though autophagy is unknown.GL-V9, a new synthesized flavonoid derivative, has been proved of its anti-tumor effects.The aim of the study is to explore the role of JNK2-related autophagy on adriamycin-induced drug resistance and the effects of GL-V9 on reversing adriamycin resistance.We concluded that JNK2 played an important role in drug resistance induced by adriamycin.The high expression of JNK2 activated protective autophagy in Hep G2-DOXR cells under non-stress condition, which protected cells from drug attacking.Furthermore, we found that GL-V9 reversed adriamycin resistance by blocking the JNK2-related protective autophagy in HCC.
引用
收藏
页码：491 / 499
页数：9
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