miRNA作为脓毒症及其并发症生物标志物的研究进展

被引：10
|
作者：
侯果 [1 ]
余追 [1 ]
机构：
[1] 武汉大学人民医院重症医学科
来源：
微循环学杂志 | 2018年 / 28卷 / 04期
关键词：
脓毒症; 生物标志物; miRNA;
D O I：
暂无
中图分类号：
R459.7 [急症、急救处理];
学科分类号：
100218 ;
摘要：
脓毒症是重症感染患者死亡的主要原因,虽然目前有许多生物标志物已被用于脓毒症的诊断和治疗,但存在一定的局限性。而微小RNA(miRNA)无蛋白质编码功能,能通过抑制mRNA的翻译或转录来调控基因的表达,从而影响疾病的发生发展,在炎症、感染和脓毒症等病理条件下,如miRNA-150、miRNA-122、miRNA-25等水平也会发生改变,并可以被快速检测。本文总结了关于miRNA在脓毒症和脓毒症引起的器官功能障碍中的研究,分析miRNA在脓毒症诊断和治疗中所起到的作用,探讨miRNA作为新的潜在生物标志物的可能性。
引用
收藏
页码：81 / 85
页数：5
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