Carcinogenesis by Nitrosamines and Azoxyalkanes by Different Routes of Administration to Rats

被引：0

作者：

WILLIAMLIJINSKY

ROBERTM.KOVATCH

机构：

[1] NCI-Frederick Cancer Research FacilityBRI-Basic Research Program Frederick

[2] Maryland

[3] NCI-Frederick Cancer Research FacilityBRI-Basic Research Program

[4] Frederick

来源：

BiomedicalandEnvironmentalSciences | 1989年 / 02期

关键词：

Carcinogenesis by Nitrosamines and Azoxyalkanes by Different Routes of Administration to Rats;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

<正> The effects of administering similar doses of some simple alkylating agents to rats by differentregimens have been compared.Two of the compounds were methylating agents,nitrosodimeth-ylamine and azoxymethane;two were ethylating agents,nitrosodiethylamine and azoxyethaneand nitrosomethylethylamine was both a methylating and an ethylating agent.The treatmentsgave rise to tumors in almost all treated rats.The results indicate the importance ofpharmacoki-netics in determining which organs are the targets of the alkylating carcinogens.1989 AcademicPress.Inc.

引用

页码：154 / 159

页数：6