Utility of co-transplanting mesenchymal stem cells in islet transplantation

被引：0
作者：
Naoaki Sakata [1 ]
Masafumi Goto [2 ,3 ]
Gumpei Yoshimatsu [1 ]
Shinichi Egawa [1 ]
Michiaki Unno [1 ]
机构：
[1] Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
[2] Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
[3] New Industry Creation Hatchery Center, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
来源：
World Journal of Gastroenterology | 2011年 / 17卷 / 47期
关键词：
Mesenchymal stem cell; Islet transplantation; Bone marrow; Immunomodulatory; Regulatory T cell; Angiogenesis; Vascular endothelial growth factor; Diabetes mellitus;
D O I：
暂无
中图分类号：
R657.5 [胰腺];
学科分类号：
1002 ; 100210 ;
摘要：
Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.
引用
收藏
页码：5150 / 5155
页数：6
相关论文
共 17 条
  • [1] Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function
    Ito, Taihei
    Itakura, Shin
    Todorov, Ivan
    Rawson, Jeffrey
    Asari, Sadaki
    Shintaku, Jonathan
    Nair, Indu
    Ferreri, Kevin
    Kandeel, Fouad
    Mullen, Yoko
    [J]. TRANSPLANTATION, 2010, 89 (12) : 1438 - 1445
  • [2] Bone Marrow Cell Cotransplantation With Islets Improves Their Vascularization and Function
    Sakata, Naoaki
    Chan, Nathaniel K.
    Chrisler, John
    Obenaus, Andre
    Hathout, Eba
    [J]. TRANSPLANTATION, 2010, 89 (06) : 686 - 693
  • [3] Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets
    Olerud, J.
    Kanaykina, N.
    Vasilovska, S.
    King, D.
    Sandberg, M.
    Jansson, L.
    Kozlova, E. N.
    [J]. DIABETOLOGIA, 2009, 52 (12) : 2594 - 2601
  • [4] Bone Marrow–Derived Mesenchymal Stem Cells Improve Islet Graft Function in Diabetic Rats[J] . M. Figliuzzi,R. Cornolti,N. Perico,C. Rota,M. Morigi,G. Remuzzi,A. Remuzzi,A. Benigni.Transplantation Proceedings . 2009 (5)
  • [5] Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia
    Solari, Mario G.
    Srinivasan, Suganya
    Boumaza, Imene
    Unadkat, Jignesh
    Harb, George
    Garcia-Ocana, Adolfo
    Feili-Hariri, Maryam
    [J]. JOURNAL OF AUTOIMMUNITY, 2009, 32 (02) : 116 - 124
  • [6] MRI Assessment of Ischemic Liver After Intraportal Islet Transplantation
    Sakata, Naoaki
    Hayes, Pete
    Tan, Annie
    Chan, Nathaniel K.
    Mace, John
    Peverini, Ricardo
    Sowers, Lawrence
    Pearce, William J.
    Chinnock, Richard
    Obenaus, Andre
    Hathout, Eba
    [J]. TRANSPLANTATION, 2009, 87 (06) : 825 - 830
  • [7] Formation of Composite Endothelial Cell-Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization[J] . Johansson, Ulrika,Rasmusson, Ida,Niclou, Simone P,Forslund, Naomi,Gustavsson, Linda,Nilsson, Bo,Korsgren, Olle,Magnusson, Peetra U.Diabetes . 2008 (9)
  • [8] Combined Islet and Hematopoietic Stem Cell Allotransplantation: A Clinical Pilot Trial to Induce Chimerism and Graft Tolerance[J] . D.Mineo,C.Ricordi,X.Xu,A.Pileggi,R.Garcia‐Morales,A.Khan,D. A.Baidal,D.Han,K.Monroy,J.Miller,A.Pugliese,T.Froud,L.Inverardi,N. S.Kenyon,R.Alejandro.American Journal of Transplantation . 2008 (6)
  • [9] Mesenchymal stem cells and neovascularization: role of platelet‐derived growth factor receptors[J] . Stephen G.Ball,C. AdrianShuttleworth,Cay M.Kielty.Journal of Cellular and Molecular Medicine . 2007 (5)
  • [10] In vivo bioluminescence imaging of transplanted islets and early detection of graft rejection
    Chen, Xiaojuan
    Zhang, Xiaomin
    Larson, Courtney S.
    Baker, Marshall S.
    Kaufman, Dixon B.
    [J]. TRANSPLANTATION, 2006, 81 (10) : 1421 - 1427
12