Utility of co-transplanting mesenchymal stem cells in islet transplantation

被引：0
|
作者：
Naoaki Sakata [1 ]
Masafumi Goto [2 ,3 ]
Gumpei Yoshimatsu [1 ]
Shinichi Egawa [1 ]
Michiaki Unno [1 ]
机构：
[1] Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
[2] Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
[3] New Industry Creation Hatchery Center, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
来源：
World Journal of Gastroenterology | 2011年 / 17卷 / 47期
关键词：
Mesenchymal stem cell; Islet transplantation; Bone marrow; Immunomodulatory; Regulatory T cell; Angiogenesis; Vascular endothelial growth factor; Diabetes mellitus;
D O I：
暂无
中图分类号：
R657.5 [胰腺];
学科分类号：
1002 ; 100210 ;
摘要：
Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.
引用
收藏
页码：5150 / 5155
页数：6
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