Mutation Analysis of IgVH Gene in B-Cell Chronic Lymphocytic Leukemia

被引：0

作者：

王峰

朱慧芬

朱丽娟

殷波涛

沈关心

机构：

来源：

华中科技大学学报(医学英德文版) | 2002年 / 03期

关键词：

immunoglobulin variable region; mutation analysis; B cell chronic lymphocytic leukemia;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Summary: The variable heavy chain region (VH) genes of 3 untreated patients with B cell chronic lymphocytic leukemia (B CLL) were cloned and analyzed. The VH family used was VH3 11, VH3 72 and VH3 33. More than 2 % difference from the corresponding germline gene was detected in all the 3 obtained potential functional genes (average 16.7). Mutation pattern analysis indicated evidence of antigen selective pressure observed in 1 of 3 cases. Our findings suggested that the tumor cells originate from post GC cells.

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页码：177 / 179+182 +182

页数：4

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