Mutation Analysis of IgVH Gene in B-Cell Chronic Lymphocytic Leukemia

被引：0
作者：
王峰
朱慧芬
朱丽娟
殷波涛
沈关心
机构：
来源：
华中科技大学学报(医学英德文版) | 2002年 / 03期
关键词：
immunoglobulin variable region; mutation analysis; B cell chronic lymphocytic leukemia;
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Summary: The variable heavy chain region (VH) genes of 3 untreated patients with B cell chronic lymphocytic leukemia (B CLL) were cloned and analyzed. The VH family used was VH3 11, VH3 72 and VH3 33. More than 2 % difference from the corresponding germline gene was detected in all the 3 obtained potential functional genes (average 16.7). Mutation pattern analysis indicated evidence of antigen selective pressure observed in 1 of 3 cases. Our findings suggested that the tumor cells originate from post GC cells.
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页码：177 / 179 +182
页数：4
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