Enhancement of Antitumor Effect of Tegafur/Uracil(UFT) plus Leucovorin by Combined Treatment with Protein-Bound Polysaccharide,PSK,in Mouse Models

被引：3

作者：

Ryoji Katoh

Mitsuru Ooshiro

机构：

[1] Chiba

[2] Department of Surgery Toho University Sakura Medical Center

[3] Japan

[4] Sakura-shi

来源：

Cellular&MolecularImmunology | 2007年 / 04期

关键词：

UFT; leucovorin; PSK; Meth A; Lewis lung carcinoma; colon; 26; antitumor effect;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

We evaluated the antitumor effect of combined therapy with tegafur/uracil(UFT) plus leucovorin(LV) (UFT/LV) and protein-bound polysaccharide,PSK,in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma,and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose,but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV,and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion,while the effect of PSK varies depending on tumor,combined use of UFT/LV and PSK may be expected to augment the antitumor effect.

引用

页码：295 / 299

页数：5

共 5 条

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[2]

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[3]

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