FREE RADICAL MECHANISM IN ENHANCEMENT OF RADIOSENSITIZATION BY SRSBR

被引：0

作者：

孙华丽

段绍瑾

余桂清

机构：

[1] Guang An Men Hospital China Academy of Traditional Chinese Medicine Beijing

[2] Guang An Men Hospital China Academy of Traditional Chinese Medicine Beijing

来源：

JournalofTraditionalChineseMedicine | 1994年 / 01期

关键词：

FREE RADICAL MECHANISM IN ENHANCEMENT OF RADIOSENSITIZATION BY SRSBR; ESR;

D O I：

10.19852/j.cnki.jtcm.1994.01.012

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

<正> The free radical mechanism of enhancing radiosensibility by the Synergic Recipe to Strengthen Body Resistance (SRSBR) consisting of 10 Chinese drugs was studied by elec-tron spin resonance (ESR) with spin trapping reagent-Nitroso-tert-butane (NtB) follow-ing irradiation of the Deoxy thymidine (dT) solution system by 60Co 3.7 PBq. The results showed SRSBR cannot only enhance the generation of e - aq but also enhance the produc-tion of · OH and H · after irradiation with γ ray in dT-NtB-SRSBR aqueous solution system. These result in damage to biological molecules, attacking and killing tumor cells radiosensitized by SRSBR. The characteristics of SRSBR for radiosensitization are con-cluded to be increasing production of · OH and H · in comparison with the well-known radiosensitizer-Misonidazole (Miso).

引用

页码：51 / 55

页数：5