FREE RADICAL MECHANISM IN ENHANCEMENT OF RADIOSENSITIZATION BY SRSBR

The free radical mechanism of enhancing radiosensibility by the Synergic Recipe to Strengthen Body Resistance (SRSBR) consisting of 10 Chinese drugs was studied by elec-tron spin resonance (ESR) with spin trapping reagent-Nitroso-tert-butane (NtB) follow-ing irradiation of the Deoxy thymidine (dT) solution system by 60Co 3.7 PBq. The results showed SRSBR cannot only enhance the generation of e - aq but also enhance the produc-tion of · OH and H · after irradiation with γ ray in dT-NtB-SRSBR aqueous solution system. These result in damage to biological molecules, attacking and killing tumor cells radiosensitized by SRSBR. The characteristics of SRSBR for radiosensitization are con-cluded to be increasing production of · OH and H · in comparison with the well-known radiosensitizer-Misonidazole (Miso).