Interactions of oxidative radicals with N-phosphoryl dipeptide derivatives

被引：0
|
作者：
储高升
陈家富
张志成
姚思德
机构：
[1] Department of Applied Chemistry
[2] University of Science and Technology of China
[3] Hefei
[4] Anhui 230026
[5] China
[6] Laboratory of Radiation Chemistry
[7] Chinese Academy of Sciences
[8] Shanghai Institute of Nuclear Research
[9] Shanghai 201800
来源：
ChineseJournalofChemistry | 1999年 / 06期
基金：
中国国家自然科学基金;
关键词：
N-Phosphoryl dipeptide; oxidation; electron transfer; pulse radiolysis;
D O I：
暂无
中图分类号：
O629 [天然化合物];
学科分类号：
摘要：
The interactions of oxidative radicals (Br2 , HO etc.) with N-phosphoryl dipeptide derivatives (NDM-TrpOMe and NDT-MetOMe) have been investigated by using pulse radiolysis at different pH values. Ithas been found that Br2 and HO radicals oxidize the Met-site and Trp-site in the dipeptide derivatives via formation of the three-electron-bonded intermediate and indolyl radical simultaneously. Then the intramolecular electron transfer along the peptide backbone occurs. The rate constants of electron transfer, k, have been determined and the reaction mechanism has been deduced.
引用
收藏
页码：592 / 598 +4
页数：8
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