Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes

被引：0
作者：
Huiyin Tu [1 ]
Dongze Zhang [1 ]
Yu-Long Li [1 ]
机构：
[1] Department of Emergency Medicine, University of Nebraska Medical Center
来源：
Neuroscience Bulletin | 2019年 / 35卷 / 01期
关键词：
Cardiovascular disease; Diabetes; Baroreflex; Baroreceptor; Vascular wall; Mechanosensitive ion channels; Voltage-gated ion channels; Angiotensin; Ⅱ; Superoxide; Nuclear factor-kappa B;
D O I：
暂无
中图分类号：
R54 [心脏、血管（循环系）疾病]; R587.1 [糖尿病];
学科分类号：
1002 ; 100201 ;
摘要：
Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and diabetes.Changes in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances(such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.
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页码：98 / 112
页数：15
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共 105 条
  • [1] Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7,Species Differences, and Regulation by Paclitaxel
    Wonseok Chang
    Temugin Berta
    Yong Ho Kim
    Sanghoon Lee
    Seok-Yong Lee
    Ru-Rong Ji
    [J]. Neuroscience Bulletin, 2018, 34 (01) : 4 - 12
  • [2] Demystifying Mechanosensitive Piezo Ion Channels[J]. X.Z.Shawn Xu.Neuroscience Bulletin. 2016(03)
  • [3] Hydrogen sulfide facilitates carotid sinus baroreceptor activity in anesthetized male rats[J]. XIAO Lin WU Yu-ming WANG Ru LIU Yi-xian WANG Fu-wei HE Rui-rong Department of Physiology,Institute of Basic Medicine,Hebei Medical Univesity,Shijiazhuang 050017,China.Chinese Medical Journal. 2007(15)
  • [4] Capsaicin facilitates carotid sinus baroreceptor activity in anesthetized rats[J]. Hao ZHANG, Yi-xian LIU, Yu-ming WU, Ze-min WANG, Rui-rong HEDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University, Shijiazhuang 050017,China.Acta Pharmacologica Sinica. 2004(11)
  • [5] Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association[J] . Emelia J. Benjamin,Michael J. Blaha,Stephanie E. Chiuve,Mary Cushman,Sandeep R. Das,Rajat Deo,Sarah D. de Ferranti,James Floyd,Myriam Fornage,Cathleen Gillespie,Carmen R. Isasi,Monik C. Jiménez,Lori Chaffin Jordan,Suzanne E. Judd,Daniel Lackland,Judith H. Lichtman,Lynda Lisabeth,Simin Liu,Chris T. Longenecker,Rachel H. Mackey,Kunihiro Matsushita,Dariush Mozaffarian,Michael E. Mussolino,Khurram Nasi
  • [6] ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters[J] . Israel Hanukoglu.The FEBS Journal . 2017 (4)
  • [7] Salvianolic Acid A Attenuates Cell Apoptosis, Oxidative Stress, Akt and NF-κB Activation in Angiotensin-II Induced Murine Peritoneal Macrophages[J] . Ling Li,Tongda Xu,Yinping Du,Defeng Pan,Wanling Wu,Hong Zhu,Yanbin Zhang,Dongye Li.Current Pharmaceutical Biotechnology . 2016 (3)
  • [8] Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction
    Weaver, Fred A.
    Abraham, William T.
    Little, William C.
    Butter, Christian
    Ducharme, Anique
    Halbach, Marcel
    Klug, Didier
    Lovett, Eric G.
    Madershahian, Navid
    Muller-Ehmsen, Jochen
    Schafer, Jill E.
    Senni, Michele
    Swarup, Vijay
    Wachter, Rolf
    Zile, Michael R.
    [J]. SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY, 2016, 28 (02) : 320 - 328
  • [9] Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana[J] . Kwame Yeboah,Daniel A. Antwi,Ben Gyan,Mario Maggi.International Journal of Endocrinology . 2016
  • [10] Effects of Baroreflex Activation Therapy on Ambulatory Blood Pressure in Patients With Resistant Hypertension
    Wallbach, Manuel
    Lehnig, Luca-Yves
    Schroer, Charlotte
    Lueders, Stephan
    Boehning, Enrico
    Mueller, Gerhard A.
    Wachter, Rolf
    Koziolek, Michael J.
    [J]. HYPERTENSION, 2016, 67 (04) : 701 - 709
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