Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

被引：0

作者：

Wan Kyu Eo ^{[1
]}

Da Wun Jeong ^{[1
]}

Hye Jung Chang ^{[1
]}

Kyu Yeoun Won ^{[2
]}

Sung Il Choi ^{[3
]}

Se Hyun Kim ^{[4
]}

Sung Wook Chun ^{[5
]}

Young Lim Oh ^{[6
]}

Tae Hwa Lee ^{[6
]}

Young Ok Kim ^{[7
]}

Ki Hyung Kim ^{[8
]}

Yong Il Ji ^{[5
]}

Ari Kim ^{[9
]}

Heung Yeol Kim ^{[6
]}

机构：

[1] Department of Hematology/Medical Oncology,Kyung Hee University Hospital at Gangdong,Seoul 134727,South Korea

[2] Department of Pathology,Kyung Hee University Hospital at Gangdong,Seoul 134727,South Korea

[3] Department of Surgery,Kyung Hee University Hospital at Gangdong,Seoul 134727,South Korea

[4] Graduate School,Dankuk University,Yongin 448701,South Korea

[5] Department of Obstetrics and Gynecology,Inje University College of Medicine,Busan 612896,South Korea

[6] Department of Obstetrics and Gynecology,Kosin University College of Medicine,Busan 602702,South Korea

[7] Department of Pathology,Kosin University College of Medicine,Busan 602702,South Korea

[8] Department of Obstetrics and Gynecology,Pusan National University Hospital,Pusan National University School of Medicine,and Biomedical Research Institute and Pusan Cancer Center,Busan 602739,South Korea

[9] Department of Obstetrics and Gynecology,Institute of Wonkwang Medical Science,College of Medicine,Wonkwang University,Iksan 570749,South Korea

来源：

World Journal of Gastroenterology | 2015年 / 21卷 / 09期

关键词：

Monocytes; Absolute lymphocyte count; Stomach neoplasms;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers.

引用

页码：2668 / 2676

页数：9

共 15 条

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