Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage,histopathological grade of malignancy and clinical features

AIM:This study was designed to compare the levels of v5and v6 splice variants of CD44 evaluated using EITSA test inthe serum of patients with colorectal cancer in differentstages of progression of the disease estimated in pT stageaccording to WHO score,histopathological grade of malignancyand some clinicopathological features.METHODS:The serum obtained from 114 persons withcolorectal adenocarcinomas was examined using ELISAmethod,pT stage and grade of malignancy of the tumourwere examined in formalin fixed and paraffin embeddedmaterials obtained during operation.RESULTS:Only the level of CD44 v5 in the serum of patientsbefore operation with G2 pT4 tumour was lower than thatin other probes and the difference was statistically significant.We did not find any other correlations between the level ofv5 and v6 CD44 variants and other evaluated parameters.CONCLUSION:The level of CD44 v5 and v6 estimated byELISA test in the serum can not be used as a prognosticfactor in colorectal cancer.