Glioblastoma vaccine tumor therapy research progress

被引：3

作者：

Zhao Tong ^{[1
,2
,3
,4
,5
,6
,7
]}

Li Chunwang ^{[1
,2
,3
,4
,5
,6
,7
]}

Ge Hongliang ^{[1
,2
,3
,4
,5
,6
,7
]}

Lin Yuanxiang ^{[1
,2
,3
,4
,5
,6
,7
]}

Kang Dezhi ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Department of Neurosurgery

[2] Neurosurgery Research Institute

[3] the First Affiliated Hospital

[4] Fujian Medical University

[5] Fuzhou

[6] Fujian Province

[7] People''s Republic of China

来源：

中华神经外科杂志（英文） | 2022年 / 08卷 / 02期

关键词：

Glioblastoma; Vaccine therapy; Immunotherapy; Tumor microenvironment; Review;

D O I：

暂无

中图分类号：

R739.4 [神经系肿瘤];

学科分类号：

100214 ;

摘要：

Glioblastoma (GBM) is the most common primary malignancy of the central nervous system in adults. The prognosis for late-stage glioblastoma (World Health Organization grade IV astrocytic glioma) is very poor. Novel treatment options are sought after and evaluated by clinicians and researchers, and remarkable advances have been made in surgical techniques, radiotherapy, and chemotherapy. However, the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few months. There has been notable progress in the field of immunotherapy, particularly with the use of tumor vaccines, for treating glioblastoma; especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell vaccines. However, the results of the current clinical trials for vaccination are not satisfactory. This article reviews the progress in the development of vaccines for glioblastoma.

引用

页码：128 / 132

页数：5

共 26 条

[1]

Therapeutic potential of marine peptides in glioblastoma: Mechanistic insights[J] . Ahmed Salman,Hasan Muhammad Mohtasheemul,Aschner Michael,Mirzaei Hamed,Alam Waqas,Mukarram Shah Syed Muhammad,Khan Haroon.Cellular signalling . 2021

[2] Inhibition of Radiation and Temozolomide-Induced Glioblastoma Invadopodia Activity Using Ion Channel Drugs [J].

Dinevska, Marija ;

Gazibegovic, Natalia ;

Morokoff, Andrew P. ;

Kaye, Andrew H. ;

Drummond, Katharine J. ;

Mantamadiotis, Theo ;

Stylli, Stanley S. .

CANCERS, 2020, 12 (10) :1-21

[3]

Near-Infrared Molecular Imaging of Glioblastoma by Miltuximab?-IRDye800CW as a Potential Tool for Fluorescence-Guided Surgery[J] . Dmitry M. Polikarpov,Douglas H. Campbell,Lucinda S. McRobb,Jiehua Wu,Maria E. Lund,Yanling Lu,Sergey M. Deyev,Andrew S. Davidson,Bradley J. Walsh,Andrei V. Zvyagin,David A. Gillatt.Cancers . 2020 (4)

[4] Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial [J].

Keskin, Derin B. ;

Anandappa, Annabelle J. ;

Sun, Jing ;

Tirosh, Itay ;

Mathewson, Nathan D. ;

Li, Shuqiang ;

Oliveira, Giacomo ;

Giobbie-Hurder, Anita ;

Felt, Kristen ;

Gjini, Evisa ;

Shukla, Sachet A. ;

Hu, Zhuting ;

Li, Letitia ;

Le, Phuong M. ;

Allesoe, Rosa L. ;

Richman, Alyssa R. ;

Kowalczyk, Monika S. ;

Abdelrahman, Sara ;

Geduldig, Jack E. ;

Charbonneau, Sarah ;

Pelton, Kristine ;

Iorgulescu, J. Bryan ;

Elagina, Liudmila ;

Zhang, Wandi ;

Olive, Oriol ;

McCluskey, Christine ;

Olsen, Lars R. ;

Stevens, Jonathan ;

Lane, William J. ;

Salazar, Andres M. ;

Daley, Heather ;

Wen, Patrick Y. ;

Chiocca, E. Antonio ;

Harden, Maegan ;

Lennon, Niall J. ;

Gabriel, Stacey ;

Getz, Gad ;

Lander, Eric S. ;

Regev, Aviv ;

Ritz, Jerome ;

Neuberg, Donna ;

Rodig, Scott J. ;

Ligon, Keith L. ;

Suva, Mario L. ;

Wucherpfennig, Kai W. ;

Hacohen, Nir ;

Fritsch, Edward F. ;

Livak, Kenneth J. ;

Ott, Patrick A. ;

Wu, Catherine J. .

NATURE, 2019, 565 (7738) :234-+

[5] Actively personalized vaccination trial for newly diagnosed glioblastoma [J].

Hilf, Norbert ;

Kuttruff-Coqui, Sabrina ;

Frenzel, Katrin ;

Bukur, Valesca ;

Stevanovic, Stefan ;

Gouttefangeas, Cecile ;

Platten, Michael ;

Tabatabai, Ghazaleh ;

Dutoit, Valerie ;

van der Burg, Sjoerd H. ;

Straten, Per Thor ;

Martinez-Ricarte, Francisco ;

Ponsati, Berta ;

Okada, Hideho ;

Lassen, Ulrik ;

Admon, Arie ;

Ottensmeier, Christian H. ;

Ulges, Alexander ;

Kreiter, Sebastian ;

von Deimling, Andreas ;

Skardelly, Marco ;

Migliorini, Denis ;

Kroep, Judith R. ;

Idorn, Manja ;

Rodon, Jordi ;

Piro, Jordi ;

Poulsen, Hans S. ;

Shraibman, Bracha ;

McCann, Katy ;

Mendrzyk, Regina ;

Loewer, Martin ;

Stieglbauer, Monika ;

Britten, Cedrik M. ;

Capper, David ;

Welters, Marij J. P. ;

Sahuquillo, Juan ;

Kiesel, Katharina ;

Derhovanessian, Evelyna ;

Rusch, Elisa ;

Bunse, Lukas ;

Song, Colette ;

Heesch, Sandra ;

Wagner, Claudia ;

Kemmer-Bruck, Alexandra ;

Ludwig, Joerg ;

Castle, John C. ;

Schoor, Oliver ;

Tadmor, Arbel D. ;

Green, Edward ;

Fritsche, Jens .

NATURE, 2019, 565 (7738) :240-+

[6]

Molecular subgroups and B7-H4 expression levels predict responses to dendritic cell vaccines in glioblastoma: an exploratory randomized phase II clinical trial[J] . Yao Yu,Luo Feifei,Tang Chao,Chen Dikang,Qin Zhiyong,Hua Wei,Xu Ming,Zhong Ping,Yu Shuangquan,Chen Di,Ding Xiaojie,Zhang Yi,Zheng Xiujuan,Yang Jiao,Qian Jiawen,Deng Yuting,Hoon Dave S B,Hu Jian,Chu Yiwei,Zhou Liangfu.Cancer immunology, immunotherapy : CII . 2018 (11)

[7]

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial[J] . Michael Weller,Nicholas Butowski,David D Tran,Lawrence D Recht,Michael Lim,Hal Hirte,Lynn Ashby,Laszlo Mechtler,Samuel A Goldlust,Fabio Iwamoto,Jan Drappatz,Donald M O’Rourke,Mark Wong,Mark G Hamilton,Gaetano Finocchiaro,James Perry,Wolfgang Wick,Jennifer Green,Yi He,Christopher D Turner,Michael J Yellin,Tibor Keler,Thomas A Dav

[8] Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy [J].

Hodges, Tiffany R. ;

Ott, Martina ;

Xiu, Joanne ;

Gatalica, Zoran ;

Swensen, Jeff ;

Zhou, Shouhao ;

Huse, Jason T. ;

de Groot, John ;

Li, Shulin ;

Overwijk, Willem W. ;

Spetzler, David ;

Heimberger, Amy B. .

NEURO-ONCOLOGY, 2017, 19 (08) :1047-1057

[9] Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma [J].

Curry, William T., Jr. ;

Gorrepati, Ramana ;

Piesche, Matthias ;

Sasada, Tetsuro ;

Agarwalla, Pankaj ;

Jones, Pamela S. ;

Gerstner, Elizabeth R. ;

Golby, Alexandra J. ;

Batchelor, Tracy T. ;

Wen, Patrick Y. ;

Mihm, Martin C. ;

Dranoff, Glenn .

CLINICAL CANCER RESEARCH, 2016, 22 (12) :2885-2896

[10]

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary[J] . Louis David N,Perry Arie,Reifenberger Guido,von Deimling Andreas,Figarella-Branger Dominique,Cavenee Webster K,Ohgaki Hiroko,Wiestler Otmar D,Kleihues Paul,Ellison David W.Acta neuropathologica . 2016 (6)

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