Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics

被引：0

作者：

Guoqing Niu ^{[1
,2
]}

Jiazhen Zheng ^{[1
,3
]}

Huarong Tan ^{[1
,3
]}

机构：

[1] State Key Laboratory of Microbial Resources,Institute of Microbiology,Chinese Academy of Sciences

[2] Biotechnology Research Center,Southwest University

[3] University of Chinese Academy of Sciences

来源：

Science China(Life Sciences) | 2017年 / 09期

关键词：

nucleoside antibiotics; biosynthesis; combinatorial biosynthesis;

D O I：

暂无

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants.Antifungal nucleoside antibiotics are an important family of natural products with distinctive structural features.Understanding their biosynthetic machinery is of great importance for the improvement of antibiotics titers.More importantly,it is a requisite for combinatorial biosynthesis to create hybrid nucleoside antibiotics.We herein focus on findings on the natural and designed biosynthesis of this important family of nucleoside antibiotics.

引用

页码：939 / 947

页数：9

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