Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers

被引：0

作者：

Zhen Ying Li a Zhao Sheng Liu a Qing Wei Zhang a Hong Quan Duan aba School of Pharmaceutical Sciences Tianjin Medical University Tianjin Chinab Basic Medical Research Center of Tianjin Tianjin Medical University Tianjin China ^{[300070
,300070
]}

机构：

来源：

ChineseChemicalLetters | 2007年 / 03期

关键词：

Molecularly imprinted polymer; Monolithic column; Naproxen; Chiral separation;

D O I：

暂无

中图分类号：

O658 [元素及化合物的分离方法];

学科分类号：

070302 ; 081704 ;

摘要：

Molecularly imprinted polymers (MIPs), using (S)-naproxen as template and the combination of butyl methacrylate (BMA) and MAA (1:1 molar ratio) as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen (Rs=1.55) and column efficiencies of imprinted molecules (N=2860 plates/m)than that with pure MAA.

引用

页码：322 / 324

页数：3

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