Synthesis, DNA-binding and photocleavage studies of ruthenium（Ⅱ） complexes [Ru（btz）]and [Ru（btz）(dppz)]

被引：0

作者：

YU HuiJuan HUANG ShuMei KOU JunFeng LI LvYing JIA HaiNa CHAO Hui JI LiangNian MOE Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical Engineering Sun YatSen University Guangzhou China ^{[510275
]}

机构：

来源：

Science in China(Series B:Chemistry) | 2009年 / 09期

关键词：

ruthenium(Ⅱ) complex; DNA binding; DNA photocleavage; PDT;

D O I：

暂无

中图分类号：

O621.1 [有机化学理论、物理有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new ruthenium(Ⅱ) complexes, [Ru(btz)3](ClO4)2 (1) and [Ru(btz)(dppz)2](ClO4)2 (2) (btz = 4,4′-bithi-azole, dppz = dipyrido[3,2-a:2′,3′-c]phenazine), have been synthesized and characterized by elemental analysis, 1H NMR, ES-MS and X-ray crystallography. The DNA binding behaviors of two complexes have been studied by spectroscopic and viscosity measurements. The results suggest that complex 1 binds to CT-DNA via an electrostatic mode, while complex 2 via an intercalative mode. Under irradiation at 365 nm, both complexes were found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form Ⅰ to nicked form Ⅱ. The mechanism studies reveal that singlet oxygen 1O2 and hydroxyl radical (OH-) play a significant role in the photocleavage process.

引用

页码：1504 / 1511

页数：8

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