Effect of PKC pathway on G1/S progression control in HeLa cells

被引：0
作者：
HU Jiang & LIU HuituDepartment of Biology
机构：
来源：
Chinese Science Bulletin | 2000年 / 05期
关键词：
PKC; cell cycle; early response gene; engine molecules;
D O I：
暂无
中图分类号：
Q26 [细胞生物化学];
学科分类号：
071009 ; 090102 ;
摘要：
The effect of PKC activity on G1/S progression in HeLa cells has been studied. The result shows that (i) PKC activity alteration in G1 phase affects d/S progression in HeLa cells. it has been observed that G1/S progression is stimulated by PKC agonist TPA and inhibited by PKC inhibitor GF-109203X. (ii) The expression of c-myc and c-jun is stimulated by TPA and inhibited by GF-109203X treatment in early G1 phase. (iii) During G1/S progression, the expression of CyciinD1is stimulated by TPA treatment and inhibited by GF-109203X treatment. There is no effect on the expression of CDK4. it is likely that PKC pathway regulates G1/S progression through regulating the expression of some early response genes and engine molecules in HeLa cells.
引用
收藏
页码：440 / 442
页数：3
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