An environmental friendly approach for the catalyst-free synthesis of highly substituted pyrazoles promoted by ultrasonic radiation

被引：0

作者：

Firouzeh Nemati ^{[1
]}

Seyed Hasan Nikkhah ^{[1
]}

Ali Elhampour ^{[1
]}

机构：

[1] Department of Chemistry, Semnan University

来源：

Chinese Chemical Letters | 2015年 / 26卷 / 11期

关键词：

Green chemistry; Multicomponent reaction; Pyrazole; Ultrasonic;

D O I：

暂无

中图分类号：

O626.21 [邻二氮杂茂（吡唑）族];

学科分类号：

070303 ; 081704 ;

摘要：

A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the reaction of various aldehydes, malononitrile and phenylhydrazine or 4-phenylthiosemicarbazide in PEG-400 and water at room temperature under ultrasound irradiation. Utilization of green solvents without a catalyst makes this methodology very interesting from economic and environmental perspectives. This method provides several advantages such as operational simplicity, use of accessible and economical starting materials and reduced environmental consequences.

引用

页码：1397 / 1399

页数：3

共 17 条

[1] Convenient synthesis of spiro [indoline-3,4'-pyrano [2,3-c] pyrazole] and spiro [acenaphthyl-3,4'-pyrano [2,3-c] pyrazoles] via fourcomponent reaction [J].

Chao Wang ;

Yan-Hong Jiang ;

Chao-Guo Yan .

Chinese Chemical Letters, 2015, 26 (07) :889-893

[2] Cesium carbonate supported on hydroxyapatite coated Ni0.5Zn0.5Fe2O4 magnetic nanoparticles as an efficient and green catalyst for the synthesis of pyrano[2,3-c]pyrazoles [J].

Farid Moeinpour ;

Amir Khojastehnezhad .

ChineseChemicalLetters, 2015, 26 (05) :575-579

[3]

Efficient synthesis of fused pyrazoles via simple cyclization of o-alkynylchalcones with hydrazine[J]. Ying Li,Chun-E.Dong.Chinese Chemical Letters. 2015(05)

[4]

Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation[J]. Jayant Sindhu,Harjinder Singh,J.M.Khurana,Chetan Sharma,K.R.Aneja.Chinese Chemical Letters. 2015(01)

[5]

Synthesis of N-substituted-2-aminobenzothiazoles using nano copper oxide as a recyclable catalyst under ligand-free conditions in reusable PEG-400 medium[J]. Satish Gaddam,Harshavardhan Reddy Kasireddy,Karnakar Konkala,Ramesh Katla,Nageswar Yadavalli Venkata Durga.Chinese Chemical Letters. 2014(05)

[6] Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles catalyzed by a simple bifunctional diaminocyclohexane-thiourea [J].

Hong-Fei Zhang ;

Zheng-Qing Ye ;

Gang Zhao .

ChineseChemicalLetters, 2014, 25 (04) :535-540

[7]

Silica chloride catalyzed one-pot synthesis of fully substituted pyrazoles[J]. Dhanaji V.Jawale,Umesh R.Pratap,Jyotirling R.Mali,Ramrao A.Mane.Chinese Chemical Letters. 2011(10)

[8]

Some Pyrazole and Pyrazolo[3,4‐ d]pyrimidine Derivatives: Synthesis and Anticancer Evaluation[J] . Ahmed H. Shamroukh,Aymn E. Rashad,Randa E. Abdel‐Megeid,Hatem S. Ali,Mamdouh M. Ali.Arch. Pharm. Chem. Life Sci. . 2014 (8)

[9]

1,3,4-Trisubstituted pyrazole analogues as promising anti-inflammatory agents[J] . S.G. Alegaon,K.R. Alagawadi,M.K. Garg,K. Dushyant,D. Vinod.Bioorganic Chemistry . 2014

[10] Anticancer activities of some newly synthesized pyrazole and pyrimidine derivatives [J].

Mohamed, Ashraf M. ;

El-Sayed, Weal A. ;

Alsharari, Musaed A. ;

Al-Qalawi, Husam R. M. ;

Germoush, Mousa O. .

ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (09) :1055-1065

← 1 2 →