TRAIL及其受体DR5、DcR1在宫颈癌中的表达

被引：2

作者：

褚静

荆亚茹

贾敏

机构：

[1] 西安医学院护理系

来源：

现代肿瘤医学 | 2009年 / 17卷 / 09期

关键词：

宫颈癌; TRAIL; DcR1; DR5; 凋亡;

D O I：

暂无

中图分类号：

R737.33 [子宫肿瘤];

学科分类号：

摘要：

目的:探讨TRAIL及其受体DR5、DcR1在宫颈癌中的表达及其临床意义。方法:应用免疫组化SP法对10例正常宫颈组织、18例宫颈上皮内瘤变(CIN)组织和40例宫颈癌组织中TRAIL、DR5及DcR1的表达情况进行检测,并结合患者年龄、肿瘤分化程度、组织类型、有无淋巴结转移等临床病理因素进行分析。结果:TRAIL及DcR1在正常宫颈组织中的表达高于宫颈癌组织;宫颈癌组织中,TRAIL阳性表达随组织学分级降低而降低;DR5在正常宫颈、CIN和宫颈癌组织中的表达呈递增趋势。结论:TRAIL、DR5及DcR1的异常表达在宫颈癌变过程中起一定的作用。

引用

页码：1749 / 1751

页数：3

共 12 条

[1] Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Ichikawa K,Liu W,Zhao L,et al. Nature Medicine . 2001
[2] Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors. Hyun-Wook Lee Seung-Hyun Lee Hae-Won Lee Yeon-Woo Ryu Myung-Hee Kwon and Yong-Sung Kim. Biochemical and Biophysical Research Communications . 2005
[3] Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Clancy,L,Mruk,K,Archer,K. Proceedings of the National Academy of Sciences of the United States of America . 2005
[4] Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Sedger LM,Glaccum MB,Schuh JC,et al. European Journal of Immunology . 2002
[5] Gene expression patterns that characterize advanced stage serous ovarian cancers. Lancaster,JM,Dressman,HK,Whitaker,RS. Journal of the Society for Gynecologic Investigation . 2004
[6] Death receptors and ligands incervical carcinogenesis an immunohistochemical study. REESINK-Peters N,HOUGARDY B M,VAN DEN HEUVEL F A,et al. Gynecologic Oncology . 2005
[7] TRAIL is a key target in Sphase slowing-dependent apoptosis induced by interferon-beta in cervical carcinoma cells. Vannucchi S,Chiantore MV,Fiorucci G,et al. Oncegene . 2005
[8] Targeting death receptors in cancer with Apo2L/TRAIL[J] . Sean K Kelley,Avi Ashkenazi. &nbspCurrent Opinion in Pharmacology . 2004 (4)
[9] Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, SR
Schooley, K
Smolak, PJ
Din, WS
Huang, CP
Nicholl, JK
Sutherland, GR
Smith, TD
Rauch, C
Smith, CA
Goodwin, RG
[J]. IMMUNITY, 1995, 3 (06) : 673 - 682
[10] Identification and characterization of a new member of the TNF family that induce apoptosis. Wiley SR,Schooley K,Smolak PJ,et al. Immunity . 1995

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