Morphological,kinetic,membrane biochemical and genetic aspects of intestinal enteroplasticity

被引：2

作者：

Laurie A Drozdowski ^{[1
]}

M Tom Clandinin ^{[2
]}

Alan BR Thomson ^{[3
]}

机构：

[1] Medical Affairs Mead Johnson Nutritionals

[2] Department of Agriculture,Food and Nutritional Sciences,University of Alberta

[3] Division of Internal Medicine,Department of Medicine,University of Alberta

来源：

World Journal of Gastroenterology | 2009年 / 15卷 / 07期

关键词：

Diabetes; Diet; Hormonal regulation; Intestinal resection; Mechanisms; Morphology; Nutrient absorption; Short bowel syndrome; Signals;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

The process of intestinal adaptation("enteroplasticity") is complex and multifaceted.Although a number of trophic nutrients and non-nutritive factors have been identified in animal studies,successful,reproducible clinical trials in humans are awaited.Understanding mechanisms underlying this adaptive process may direct research toward strategies that maximize intestinal function and impart a true clinical benefit to patients with short bowel syndrome,or to persons in whom nutrient absorption needs to be maximized.In this review,we consider the morphological,kinetic and membrane biochemical aspects of enteroplasticity,focus on the importance of nutritional factors,provide an overview of the many hormones that may alter the adaptive process,and consider some of the possible molecular profiles.While most of the data is derived from rodent studies,wherever possible,the results of human studies of intestinal enteroplasticity are provided.

引用

页码：774 / 787

页数：14

共 60 条

[31]

Small Intestinal Na+,K+-Adenosine Triphosphatase Activity and Gene Expression in Experimental Diabetes Mellitus[J] . G. E. Wild,J. A. Thompson,L. Searles,R. Turner,J. Hasan,A. B. R. Thomson.Digestive Diseases and Sciences . 1999 (2)

[32]

Expression of SPARC （Secreted Protein, Acidic and Rich in Cysteine） in Healing Intestinal Anastomoses and Short Bowel Syndrome in Rats[J] . Pauli Puolakkainen,May Reed,Palvi Vento,E. Helene Sage,Tuula Kiviluoto,Eero Kivilaakso.Digestive Diseases and Sciences . 1999 (8)

[33]

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES[J] . D. A. Brown,E. London.Annual Review of Cell and Developmental Biology . 1998

[34] Enteral ornithine α-ketoglutarate enhances intestinal adaptation to massive resection in rats [J].

Dumas, F ;

De Bandt, JP ;

Colomb, V ;

Le Boucher, J ;

Coudray-Lucas, C ;

Lavie, S ;

Brousse, N ;

Ricour, C ;

Cynober, L ;

Goulet, O .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (11) :1366-1371

[35]

Systemic Short-Chain Fatty Acids Rapidly Alter Gastrointestinal Structure, Function, and Expression of Early Response Genes[J] . Kelly A. Tappenden,Michael I. Mcburney.Digestive Diseases and Sciences . 1998 (7)

[36] Enhancement of intestinal adaptation by hepatocyte growth factor [J].

Kato, Y ;

Yu, DH ;

Schwartz, MZ .

JOURNAL OF PEDIATRIC SURGERY, 1998, 33 (02) :235-239

[37] Does growth hormone and glutamine enhance bowel absorption? [J].

Byrne, T ;

Wilmore, D .

GASTROENTEROLOGY, 1998, 114 (05) :1110-1111

[38] Human growth hormone induces system B transport in short bowel syndrome [J].

Iannoli, P ;

Miller, JH ;

Ryan, CK ;

Gu, LH ;

Ziegler, TR ;

Sax, HC .

JOURNAL OF SURGICAL RESEARCH, 1997, 69 (01) :150-158

[39] Short-bowel syndrome in children and adults [J].

Vanderhoof, JA ;

Langnas, AN .

GASTROENTEROLOGY, 1997, 113 (05) :1767-1778

[40]

Effect of growth hormone, glutamine, and diet on adaptation in short- bowel syndrome: A randomized, controlled study[J] . JS Scolapio,M Camilleri,CR Fleming,LV Oenning,DD Burton,TJ Sebo,KP Batts,DG Kelly.Gastroenterology . 1997 (4)

← 1 2 3 4 5 6 →