Regulation effect of vascular endothelial growth factor on vascularization and angiogenesis in developmental human fetal retinas

被引：0

作者：

SONG Yue ZHAO Jin song ZHANG Xiao guang WANG Yi Department of OphthalmologySecond HospitalJilin UniversityChangchun China Jinlin Dipensary of OphthalmopathyChangchun China ^{[1
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机构：

来源：

白求恩医科大学学报 | 2001年 / 03期

关键词：

human fetus; retina; blood vessels; proliferation cell nuclear antigen (PCNA); vascular endothelial growth factor (VEGF);

D O I：

10.13481/j.1671-587x.2001.03.001

中图分类号：

R714.7 [围产期医学];

学科分类号：

100211 ;

摘要：

目的 :研究血管内皮生长因子 ( Vascular endothelial growth factor VEGF)对人胚胎视网膜血管发生的调节作用。方法 :收集 54例 9～ 4 0周龄胎儿眼球后壁标本 ,免疫组织化学染色 ,光镜观察。结果 :1VEGF在视网膜的表达呈波峰式分布 ,高峰在 9～ 13周及 2 6周左右。 2节细胞层的梭形细胞(血管内皮细胞前体细胞 )、血管内皮细胞呈增殖细胞核抗原 ( Proliferation cell nucelear antigen,PCNA)免疫反应阳性 ,水平波动 ,高峰在 9～ 13周及 2 1周前后 ,此期间梭形细胞不断增殖、分化形成内皮细胞索 ,经改建形成视网膜内层血管 ,2 6、34周起见内核层内、外缘血管内皮细胞呈 PCNA免疫反应阳性 ,并保持至足月。 3视网膜 VEGF表达量与梭形细胞、血管内皮细胞 PCNA表达量呈显著正相关( r=0 .736,P<0 .0 1)。结论 :VEGF对视网膜内层及外层血管发生均有促进作用

引用

页码：221 / 225

页数：5

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