A high-resolution small animal SPECT system developed at Tsinghua

被引：0
作者：
DAI Tiantian MATianyu~* LIU Hui CUI Junjian WEI Qingyang LIU Yaqiang WANG Shi Key Laboratory of Particle & Radiation Imaging
Department of Engineering Physics
机构：
来源：
NuclearScienceandTechniques | 2011年 / 22卷 / 06期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
SPECT; Multi-pinhole collimator; High resolution; System matrix; Image reconstruction;
D O I：
10.13538/j.1001-8042/nst.22.344-348
中图分类号：
Q95-3 [动物学的研究与实验];
学科分类号：
071002 ;
摘要：
An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It was developed from a single-head clinical SPECT scanner,with a seven-pinhole collimator and a four-degree-offreedom motion control stage.Several key techniques were developed,including high-resolution image reconstruction algorithm,high accuracy geometrical calibration method,and optimized system matrix derivation scheme.The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function.Experiments of point source and ultra micro hot rod phantom were conducted.With a spatial resolution of 0.5-0.6 mm,this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.
引用
收藏
页码：344 / 348
页数：5
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