Indicators of fatal outcome in severe Plasmodium falciparum malaria:a study in a tertiary-care hospital in Thailand

被引：4

作者：

Noppadon Tangpukdee ^{[1
]}

Khin Myat Wai ^{[1
]}

Sant Muangnoicharoen ^{[1
]}

Shigeyuki Kano ^{[2
]}

Nanthaporn Phophak ^{[3
]}

Janram Tiemprasert ^{[3
]}

Srivicha Krudsood ^{[4
]}

Polrat Wilairatana ^{[1
,5
]}

机构：

[1] Critical Care Research Unit,Department of Clinical Tropical Medicine,Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand

[2] Department of Tropical Medicine and Malaria,Research Institute,National Center for Global Health and Medicine(NCGM),Tokyo,Japan 3. Hospital for Tropical Diseases,Faculty of Tropical Medicine,Mahidol

[3] WHO Collaborating Center for Clinical Management of Malaria,Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand

来源：

Asian Pacific Journal of Tropical Medicine | 2010年 / 3卷 / 11期

关键词：

Plasmodium falciparum; Severe malaria; Fatal indicator; Tertiary care; Thailand;

D O I：

暂无

中图分类号：

R531.3 [疟疾];

学科分类号：

1002 ; 100201 ;

摘要：

Objective:To illustrate the clinical features and investigate the indicators associated with a fatal outcome in adult patients with severe Plasmodium falciparum malaria admitted to the Hospital for Tropical Diseases,Bangkok,Thailand.Methods:We studied 202 adult malaria patients admitted to the Intensive Care Unit.A total of 43 clinical variables were identified by univariate and logistic regression analyses,to eliminate confounding factors.Results:Regarding the statistical methods,only 6 variables-jaundice,cerebral malaria,metabolic acidosis,body mass index,initial respiratory rate,and white blood cell count-were significant indicators of death, with adjusted odds ratios(95%CI) of 15.2(2.1-32.3).4.3(2.3-12.6),3.3(2.3-5.7),2.4(1.9-3.5),2.2 (1.5-2.6),and 1.7(1.2-3.1),respectively.Conclusions:Our study found that jaundice,cerebral malaria,metabolic acidosis,body mass index,initial respiratory rate and white blood cell count were indicators of fatal outcome in severe Plasmodium falciparum malaria.Further studies on the fatal indicators in severe malaria need to be compared with data from different geographical areas,to construct practical measures to address potentially fatal indicators in different settings.

引用

页码：855 / 859

页数：5