Gastric adenocarcinoma of fundic gland type after Helicobacter pylori eradication:A case report

BACKGROUND Gastric adenocarcinoma of fundic gland type(GA-FG)has recently been proposed as a novel histological type of gastric cancer.CASE SUMMARY We report a case of GA-FG in a 77-year-old Chinese woman with epigastric distention who was referred to endoscopy for the management of an incidentally found submucosal tumor-like elevated lesion in the lower part of the gastric body.The tumor occurred after Helicobacter pylori(H.pylori)eradication therapy without long-term use of proton pump inhibitors.Complete and curable removal of the tumor was performed by endoscopic submucosal dissection.Histopathological findings showed numerous cells with basophilic cytoplasm and mildly atypical nuclei-like chief cells of the fundic gland.The tumor was observed to have the so-called "endless glands" pattern of the well-differentiated mixed phenotype.A safe resection margin without lymphatic and venous invasion was observed.As the tumor occurred after H.pylori eradication therapy,it is unknown whether there was a relationship with H.pylori eradication.The patient will be followed up by periodic gastroscopic observation.CONCL USION In conclusion,we report a case of GA-FG after H.pylori eradication therapy without long-term proton pump inhibitors use.Further analysis of similar cases will reveal the clinical behavior of GA-FG.