Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases

被引：0
|
作者：
Tadahiro Numakawa [1 ]
机构：
[1] Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry,4-1-1, Ogawa-Higashi, Kodaira, Tokyo, Japan
来源：
NeuralRegenerationResearch | 2014年 / 9卷 / 16期
关键词：
neurodegenerative diseases; BDNF; TrkB; natural compounds; neuroprotection;
D O I：
暂无
中图分类号：
R774.6 [视神经疾病];
学科分类号：
100212 ;
摘要：
It has been suggested that altered levels/function of brain-derived neurotrophic factor(BDNF) play a role in the pathophysiology of neurodegenerative diseases including Alzheimer’s disease. BDNF positively contributes to neural survival and synapse maintenance via stimulating its high affinity receptor TrkB, making upregulation of BDNF and/or activation of BDNF-related intracellular signaling an attractive approach to treating neurodegenerative diseases. In this short review, I briefly introduce small natural compounds such as flavonoids that successfully increase activation of the BDNF system and discuss their beneficial effects against neurodegeneration.
引用
收藏
页码：1506 / 1508
页数：3
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