Cell-specific mineralocorticoid receptors:future therapeutic targets for stroke?

被引:0
|
作者
Quynh N.Dinh [1 ]
Grant R.Drummond [1 ]
Christopher G.Sobey [1 ]
Sophocles Chrissobolis [2 ]
机构
[1] Vascular Biology & Immunopharmacology Group,Cardiovascular Disease Program and Department of Pharmacology,Biomedicine Discovery Institute,Monash University
[2] Department of Pharmaceutical and Biomedical Sciences,Raabe College of Pharmacy,Ohio Northern University
基金
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
MR; MCAO;
D O I
暂无
中图分类号
R977 [影响生长代谢机能药物];
学科分类号
摘要
The mineralocorticoid receptor(MR),well known to be expressed in renal epithelial cells where it is important in fluid and electrolyte homeostasis,has aldosterone as one of its main agonists.Much research in the last 10–15 years indicates that MRs are also expressed outside of the kidney,including in the brain,vasculature and heart,where they contribute to the pathophysiology of disease(Dinh et al.,2012
引用
收藏
页码:1230 / 1231
页数:2
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