Pharmacological and therapeutic properties of the Red Clover(Trifolium pratense L.): an overview of the new findings

OBJECTIVE: To review beneficial effects of red clover(Trifolium pratense L.) on biological processes.METHODS: A systematic review was carried out according tothe PRISMA checklist. Using Me SH keywords, 385 articles were extracted from national and international databases(Pub Med, Science Direct, SID, and Google Scholar search engine) without time limit. After removing duplicates, 80 articles were reviewed.RESULTS: Our findings revealed that the compositions of red clover promote anti-oxidant and anti-cancer effects. Furthermore, they exude beneficial effects on cardiovascular functionand improvesymptoms of menopause. Also, these compounds can regulate blood glucose and lipid markers. The effects of the herb on have also been investigated on various tissues including endometrium, breast,skin and reproductive system.CONCLUSION: In recent studies, the anti-cancer effects of clover(Trifolium) extract co-administrated with standard drugs have been reportedin different cancers.