Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer

被引：0

作者：

Kai Huang ^{[1
,2
]}

Rongfa Yuan ^{[1
]}

Kai Wang ^{[1
]}

Junwen Hu ^{[1
]}

Zixi Huang ^{[1
]}

Chen Yan ^{[1
]}

Wei Shen ^{[1
]}

Jianghua Shao ^{[1
,3
]}

机构：

[1] Department of General Surgery,Second Affiliated Hospital of Nanchang University

[2] Department of Gastrointestinal Surgery,Jiangxi Provincial Cancer Hospital

[3] Jiangxi Province Key Laboratory of Molecular Medicine

来源：

ChineseJournalofCancerResearch | 2014年 / 26卷 / 01期

关键词：

Homeobox B9(HOXB9); colon cancer; prognostic; invasion; metastasis;

D O I：

暂无

中图分类号：

R735.35 [];

学科分类号：

100214 ;

摘要：

Objective:Homeobox B9(HOXB9) is proposed to be involved in tumor angiogenesis and metastasis.We investigated the role of HOXB9 in the progression of colon cancer.Methods:HOXB9 expression was investigated by immunohistochemically and Western blotting in 128 colon cancer patients and the results were analyzed statistically associated with clinicopathological data and survival of the patients.The effect of HOXB9 on cell invasion and metastases abilities were analyzed in vitro and in vivo.Results:HOXB9 is overexpressed in colon cancer tissues and significantly correlated with metastasis and poor survival of patients(P<0.05,respectively).Additionally,high levels of expression of HOXB9 were observed in metastatic lymph nodes.The down-regulation of HOXB9 expression can inhibit the migration and invasive ability of colon cancer cells,while exogenous expression of HOXB9 in colon cancer cells enhanced cell migration and invasiveness.Moreover,stable knockdown of HOXB9 reduced the liver and lung metastasis of colon cancer in vivo.Conclusions:HOXB9 may play an important role in the invasion and metastasis of colon cancer cells and may be a useful biomarker for metastasis and prognostic of colon cancer.

引用

页码：72 / 80

页数：9

共 15 条

[1] Lymph node staging in colorectal cancer:Old controversies and recent advances [J].

Annika Resch ;

Cord Langner .

World Journal of Gastroenterology, 2013, (46) :8515-8526

[2]

FAT10 protects cardiac myocytes against apoptosis[J] . Xiaogang Peng,Jianghua Shao,Yang Shen,Yunguo Zhou,Qing Cao,Jinzhu Hu,Wenfeng He,Xin Yu,Xiuxia Liu,Ali J. Marian,Kui Hong.Journal of Molecular and Cellular Cardiology . 2013

[3] Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice [J].

Bakker, Elvira R. M. ;

Das, Asha Mooppilmadham ;

Helvensteijn, Werner ;

Franken, Patrick F. ;

Swagemakers, Sigrid ;

van der Valk, Martin A. ;

ten Hagen, Timo L. M. ;

Kuipers, Ernst J. ;

van Veelen, Wendy ;

Smits, Ron .

CARCINOGENESIS, 2013, 34 (11) :2629-2638

[4] Meeting the biologic challenge of colorectal metastases [J].

Wanebo, Harold J. ;

LeGolvan, Mark ;

Paty, Philip B. ;

Saha, Sukamal ;

Zuber, Markus ;

D'Angelica, Michael I. ;

Kemeny, Nancey E. .

CLINICAL & EXPERIMENTAL METASTASIS, 2012, 29 (07) :821-839

[5]

Cancer statistics for Hispanics/Latinos, 2012[J] . Rebecca Siegel,Deepa Naishadham,Ahmedin Jemal.CA: A Cancer Journal for Clinicians . 2012 (5)

[6]

Homeodomain‐containing protein HOXB 9 regulates expression of growth and angiogenic factors, facilitates tumor growth in?vitro and is overexpressed in breast cancer tissue[J] . Bishakha Shrestha,Khairul I. Ansari,Arunoday Bhan,Sahba Kasiri,Imran Hussain,Subhrangsu S. Mandal.FEBS J . 2012 (19)

[7] Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular carcinoma cells [J].

Liu, Tiande ;

Yu, Xin ;

Li, Guohui ;

Yuan, Rongfa ;

Wang, Qingnuo ;

Tang, Ping ;

Wu, Linquan ;

Liu, Xiuxia ;

Peng, Xiaogang ;

Shao, Jianghua .

EXPERIMENTAL CELL RESEARCH, 2012, 318 (16) :1994-2003

[8] HOXB9 Expression Promoting Tumor Cell Proliferation and Angiogenesis Is Associated with Clinical Outcomes in Breast Cancer Patients [J].

Seki, Hirohito ;

Hayashida, Tetsu ;

Jinno, Hiromitsu ;

Hirose, Shigemichi ;

Sakata, Michio ;

Takahashi, Maiko ;

Maheswaran, Shyamala ;

Mukai, Makio ;

Kitagawa, Yuko .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (06) :1831-1840

[9]

Identification of a Novel Binding Protein of FAT10: Eukaryotic Translation Elongation Factor 1A1[J] . Xin Yu,Xiuxia Liu,Tiande Liu,Kui Hong,Jun Lei,Rongfa Yuan,Jianghua Shao.Digestive Diseases and Sciences . 2012 (9)

[10]

Prognostic Value of the Lymph Node Ratio in Stage III Colorectal Cancer: A Systematic Review[J] . W. Ceelen,Y. Nieuwenhove,P. Pattyn.Annals of Surgical Oncology . 2010 (11)

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