Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury

被引：0

作者：

Xiao-ge Yan ^{[1
]}

Bao-hua Cheng ^{[2
]}

Xin Wang ^{[2
]}

Liang-cai Ding ^{[2
]}

Hai-qing Liu ^{[3
]}

Jing Chen ^{[2
]}

Bo Bai ^{[2
]}

机构：

[1] Xinxiang Medical University

[2] Neurobiology Institute,Jining Medical University

[3] Taishan Medical University

来源：

Neural Regeneration Research | 2015年 / 10卷 / 05期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; brain injury; neuroprotection; cerebral ischemia/reperfusion injury; lateral intracerebroventricular injection; Apelin-13; nerve apoptosis; Bcl-2; caspase-3; NSFC grants; neural regeneration;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

Apelin-13 inhibits neuronal apoptosis caused by hydrogen peroxide,yet apoptosis following cerebral ischemia-reperfusion injury has rarely been studied.In this study,Apelin-13(0.1 μg/g) was injected into the lateral ventricle of middle cerebral artery occlusion model rats.TTC,TUNEL,and immunohistochemical staining showed that compared with the cerebral ischemia/reperfusion group,infarct volume and apoptotic cell number at the ischemic penumbra region were decreased in the Apelin-13 treatment group.Additionally,Apelin-13 treatment increased Bcl-2 immunoreactivity and decreased caspase-3 immunoreactivity.Our findings suggest that Apelin-13 is neuroprotective against cerebral ischemia/reperfusion injury through inhibition of neuronal apoptosis.

引用

页码：766 / 771

页数：6

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