Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury

被引：0
|
作者：
Xiao-ge Yan [1 ]
Bao-hua Cheng [2 ]
Xin Wang [2 ]
Liang-cai Ding [2 ]
Hai-qing Liu [3 ]
Jing Chen [2 ]
Bo Bai [2 ]
机构：
[1] Xinxiang Medical University
[2] Neurobiology Institute,Jining Medical University
[3] Taishan Medical University
来源：
Neural Regeneration Research | 2015年 / 10卷 / 05期
基金：
中国国家自然科学基金;
关键词：
nerve regeneration; brain injury; neuroprotection; cerebral ischemia/reperfusion injury; lateral intracerebroventricular injection; Apelin-13; nerve apoptosis; Bcl-2; caspase-3; NSFC grants; neural regeneration;
D O I：
暂无
中图分类号：
R743 [脑血管疾病];
学科分类号：
1002 ;
摘要：
Apelin-13 inhibits neuronal apoptosis caused by hydrogen peroxide,yet apoptosis following cerebral ischemia-reperfusion injury has rarely been studied.In this study,Apelin-13(0.1 μg/g) was injected into the lateral ventricle of middle cerebral artery occlusion model rats.TTC,TUNEL,and immunohistochemical staining showed that compared with the cerebral ischemia/reperfusion group,infarct volume and apoptotic cell number at the ischemic penumbra region were decreased in the Apelin-13 treatment group.Additionally,Apelin-13 treatment increased Bcl-2 immunoreactivity and decreased caspase-3 immunoreactivity.Our findings suggest that Apelin-13 is neuroprotective against cerebral ischemia/reperfusion injury through inhibition of neuronal apoptosis.
引用
收藏
页码：766 / 771
页数：6
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