Optimising gene therapy of hypoparathyroidism with hematopoietic stem cells

被引：0
作者：
ZHOU Yi
机构：
来源：
中华医学杂志(英文版) | 2005年 / 03期
关键词：
parathyroid hormone · gene therapy · retroviral vectors · hematopoietic stem cells · transfection;
D O I：
暂无
中图分类号：
R582.2 [];
学科分类号：
1002 ; 100201 ;
摘要：
Background The treatment of hypoparathyroidism (HPT) is still a difficult clinical problem, which necessitates a new therapy. Gene therapy of HPT has been valuable, but how to improve the gene transfer efficiency and expression stability is a problem. This study was designed to optimize the gene therapy of HPT with hematopoietic stem cells (HSCs) recombined with the parathyroid hormone (PTH) gene.
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页码：29 / 34
页数：6
相关论文
共 11 条
[1]  
Retroviralexpressioninembryonicstemcellsandhematopoieticstemcells. CherrySR,BiniszkiewiczD,VanPL, etal. Molecular and Cellular Biology . 2000
[2]  
Theproblemsandtacticsongenetherapyofhematopoieticstemcells. LuHZ,XueJL. ChinJHemat . 2000
[3]  
Animprovedvectorforhigh level, consistentretroviraltransgeneexpressioninhumanthymocytesaftercompetitivereconstitutionfromtransducedperipheralbloodstemcells. AustinTW,MossK,MorelF, etal. Human Gene Therapy . 2001
[4]  
Developmentofgenetherapyforhematopoieticstemcellusingviralvectors. DongWJ,ZuZX,LiuDP, etal. ActaGenetSin . 2003
[5]  
Safety testing for replication competent retrovirus associated with gibbon ape leukemia virus-pseudotyped retroviral vectors. Chen J,Reeves L,Cornetta K. Human Gene Therapy . 2001
[6]  
Comparisonofthreeretroviralvectorsystemsfortransductionofnonobesediabetic/SeverecombinedimmunodeficiencymicerepopulatinghumanCD34(+)cordbloodcells. LeursC,JansenM,PollokKE, etal. Human Gene Therapy . 2003
[7]  
Hypoparathy roidismandsyndromeofhypocalcemia. KorolevskaiaLI,Luk’ianchikovVS. Klinicheskaia Meditsina . 2003
[8]  
SmallincreasesinpHenhanceretroviralvectortransductionefficiencyofNIH 3T3cells. JensenTW,ChenY,MillerWM. Biotechnology Letters . 2003
[9]  
Lentivirus basedvectorstransducemousehematopoieticstemcellswithsimilarefficiencytoMoloneymurineleukemiavirus basedvectors. BarretteS,DonglasJL,SeidelNE, etal. Blood . 2000
[10]  
Thecloneandidentificationofhumanparathyroidhormonegene. ZhangWH,SongC,MengSS, etal. NatlMedJChina . 2000
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