Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?

被引：0
|
作者：
Jing Ge [1 ,2 ]
Jun Wang [2 ]
Dan Xue [3 ]
Zhengsheng Zhu [4 ]
Zhenyu Chen [3 ]
Xiaoqiu Li [2 ]
Dongfeng Su [5 ]
Juan Du [1 ]
机构：
[1] Department of Gynecology and Obstetrics,Shengjing Hospital of China Medical University
[2] The General Hospital of Shenyang Military Region
[3] Department of Gynecology and Obstetrics,People's Liberation Army No.202 Hosiptal
[4] Dantu District Sanitary Supervision Institute
[5] Department of Neurology,the 463 Hospital of Chinese PLA
来源：
NeuralRegenerationResearch | 2013年 / 8卷 / 20期
关键词：
neural regeneration; preeclampsia; eclampsia; excitatory neurotransmitter; neurotoxicity; hyperlip-idemia; hypertension; pregnancy; lipoprotein-associated phospholipase A2; metabotropic glutamate receptor 1; grants-supported paper; neuroregeneration;
D O I：
暂无
中图分类号：
R714.245 [];
学科分类号：
摘要：
Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hyper-tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein ex-pressions were upregulated in the rat hippocampus. These findings indicate that increased expres-sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced pree-clampsia in pregnant rats.
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收藏
页码：1872 / 1880
页数：9
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