NMD机制及其对人类遗传病的治疗意义

被引：2

作者：

胡建燃

李平

机构：

[1] 长治学院生物科学与技术系

来源：

生命科学研究 | 2016年 / 20卷 / 06期

关键词：

无义介导的mRNA降解机制(NMD); 真核生物细胞; 提前终止子(PTC); 人类遗传病;

D O I：

10.16605/j.cnki.1007-7847.2016.06.013

中图分类号：

R596 [遗传性疾病];

学科分类号：

1002 ; 100201 ;

摘要：

无义介导的mRNA降解机制(nonsense-mediated mRNA decay,NMD)是真核细胞内重要的RNA质量监控机制,能够识别并降解含有提前终止子(premature termination codon,PTC)的mRNA,避免细胞内积累有害的截短蛋白质产物。同时,NMD机制还调控着大量不含PTC的mRNA稳定性,影响其蛋白质产物的含量。现综述了NMD机制的底物、调控因子及其对人类遗传病治疗意义的最新研究进展。

引用

页码：535 / 541

页数：7

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