Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity

被引：0

作者：

LI Jie-Hong

PAN Jie-Tao

YIN Yong-Qin

机构：

[1] DepartmentofTraditionalChineseMedicinalChemistry,GuangdongPharmaceuticalUniversity

来源：

Chinese Journal of Natural Medicines | 2016年 / 14卷 / 03期

关键词：

Ipomoea cairica; Resin glycoside; Simonic acid A; α-Glucosidase;

D O I：

暂无

中图分类号：

R284 [中药化学]; R285 [中药药理学];

学科分类号：

1008 ;

摘要：

In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC50 values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L-1, respectively.

引用

页码：227 / 231

页数：5

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