IL-18 and IL-18 binding protein levels in patients with dengue virus infection

被引：0
|
作者：
Chintana Chirathaworn [1 ]
Yong Poovorawan [2 ]
Viboonsak Vuthitanachot [3 ]
机构：
[1] Department of Microbiology,Faculty of Medicine,Chulalongkorn University
[2] Department of Pediatrics,Faculty of Medicine,Chulalongkorn University
[3] Chumphae Hospital
来源：
Asian Pacific Journal of Tropical Medicine | 2010年 / 3卷 / 10期
关键词：
Dengue virus; IL-18; IL-18BP;
D O I：
暂无
中图分类号：
R512.8 [病毒性出血热];
学科分类号：
100401 ;
摘要：
Objective:To determine the levels of IL-18 and IL-18 binding protein(BP) in patients with dengue virus infection.Methods:Acute and convalescent sera were collected from each patient. Control group was sera from blood donors.The levels of both IL-18 and IL-18BP were measured by ELISA assays.Results:It was shown that IL-18 and IL-18BP levels were significantly higher in patients when compared with controls.In addition,the level of IL-18BP was lower in convalescent than in acute sera.Conclusions:These data suggest that both IL-18 and IL-18BP production was induced following dengue virus infection.Investigating the regulation of IL-18 by its natural regulator could lead to further understanding of the immune response or immunopathogenesis following dengue virus infection.
引用
收藏
页码：812 / 814
页数：3
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