Low serum levels of ghrelin are associated with gallstone disease

被引：0

作者：

Nahum Méndez-Sánchez ^{[1
]}

Guadalupe Ponciano-Rodríguez ^{[2
]}

Luisa Bermejo-Martínez ^{[3
]}

Antonio R Villa ^{[4
]}

Norberto C Chávez-Tapia ^{[1
]}

Daniel Zamora-Valdés ^{[1
]}

Raúl Pichardo-Bahena ^{[1
]}

Blanca Barredo-Prieto ^{[1
]}

Martha H Uribe-Ramos ^{[1
]}

Martha H Ramos ^{[1
]}

Héctor A Baptista-González ^{[3
]}

Misael Uribe ^{[1
]}

机构：

[1] Liver Unit Biomedical Research Department,Medica Sur Clinic and Foundation,Mexico City,Mexico 2. Faculty of Medicine National Autonomous University of Mexico (UNAM),Mexico City,Mexico

来源：

World Journal of Gastroenterology | 2006年 / 19期

关键词：

Gallstones; Obesity; Ghrelin; Gallbladder; Gastrointestinal hormones;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

AIM: To explore the role of ghrelin in gallstone disease. METHODS: We carried out a cross-sectional study in 150 subjects, 38 with gallstones (cases) and 112 controls. We also did a real-time PCR-RT study in twenty gallbladder samples each. Body mass index (BMI), serum insulin, ghrelin, and serum lipids were measured. Logistic regression analyses (univariate and multivariate) were conducted to estimate the probability of gallstone disease associated with serum ghrelin concentrations. RESULTS: Cases were statistically different from controls in gender distribution (P = 0.01), age (53 vs 44 yr, P = 0.002), BMI (28 vs 25; P = 0.004), and glucose (5.26 vs 4.98 mmol/L; P = 0.05). The prevalence of ghrelin serum levels above the third tercile was lower in subjects without metabolic syndrome (P < 0.05). In a multivariate model, we found a protective effect, when ghrelin values were higher than the median value (OR = 0.27, 95%CI 0.09-0.82, P = 0.02). Twenty (20%) gallbladder specimens expressed ghrelin mRNA. CONCLUSION: Serum ghrelin concentrations are associated with a protective effect of GD.

引用

页码：3096 / 3100

页数：5

共 4 条

[1] Effects of growth hormone deficiency and recombinant growth hormone therapy on postprandial gallbladder motility and cholecystokinin release
Moschetta, A
Twickler, TB
Rehfeld, JF
Van Ooteghem, NAM
Cabezas, MC
Portincasa, P
Van Berge-Henegouwen, GP
Van Erpecum, KJ
[J]. DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (03) : 529 - 534
[2] Interdigestive Gallbladder Emptying, Antroduodenal Motility, and Motilin Release Patterns Are Altered in Cholesterol Gallstone Patients[J] . M.F.J. Stolk,K.J. Van Erpecum,T.L. Peeters,M. Samsom,A.J.P.M. Smout,L.M.A. Akkermans,G.P. Vanberge-Henegouwen.Digestive Diseases and Sciences . 2001 (6)
[3] Prevalence of gallstone disease in Mexico[J] . Nahum Méndez-Sánchez,José Jessurun,Guadalupe Ponciano-Rodríguez,Patricia Alonso-De-Ruiz,Misael Uribe,Mauricio Hernández-Avila.Digestive Diseases and Sciences . 1993 (4)
[4] Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man[J] . D. R. Matthews,J. P. Hosker,A. S. Rudenski,B. A. Naylor,D. F. Treacher,R. C. Turner.Diabetologia . 1985 (7)

← 1 →