Gastrointestinal mucosal immunity and COVID-19

被引：0

作者：

Tsvetelina Velikova ^{[1
]}

Violeta Snegarova ^{[2
]}

Alexander Kukov ^{[1
]}

Hristiana Batselova ^{[3
]}

Antoaneta Mihova ^{[1
]}

Radislav Nakov ^{[4
]}

机构：

[1] Department of Clinical Immunology,University Hospital Lozenetz,Medical Faculty,Sofia University

[2] Clinic of Internal Diseases,Naval Hospital–Varna,Military Medical Academy,Medical Faculty,Medical University

[3] Department of Epidemiology and Disaster Medicine,Medical University,Plovdiv,University Hospital "St George"

[4] Clinic of Gastroenterology,Tsaritsa Joanna University Hospital,Medical University of Sofia

来源：

World Journal of Gastroenterology | 2021年 / 30期

关键词：

D O I：

暂无

中图分类号：

R563.1 [肺炎];

学科分类号：

1002 ; 100201 ;

摘要：

As the gastrointestinal tract may also be a crucial entry or interaction site of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), the role of the gut mucosal immune system as a first-line physical and immunological defense is critical. Furthermore, gastrointestinal involvement and symptoms in coronavirus disease 2019(COVID-19) patients have been linked to worse clinical outcomes. This review discusses recent data on the interactions between the virus and the immune cells and molecules in the mucosa during the infection. By carrying out appropriate investigations, the mucosal immune system role in SARS-CoV-2 infection in therapy and prevention can be established. In line with this, COVID-19 vaccines that stimulate mucosal immunity against the virus may have more advantages than the others.

引用

页码：5047 / 5059

页数：13

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