Heterogeneity of the intrahepatic biliary epithelium

被引:0
作者
Shannon Glaser
Heather Francis
Sharon DeMorrow
Gene LeSage
Giammarco Fava
Marco Marzioni
Julie Venter
Gianfranco Alpini
机构
[1] Central Texas Veterans Health Care System Department of Medicine
[2] College of Medicine
[3] Department of Gastroenterology Universita Politecnica delle Marche Azienda Ospedaliera "Ospedali Riuniti di Ancona" Ancona Italy
[4] Department of Medicine Division of Research and Education Scott & White Memorial Hospital and The Texas A&M University System Health Science Center
[5] Department of Medicine Scott & White Memorial Hospital and The Texas A&M University System Health Science Center
[6] Sharon DeMorrow Division of Research and Education
[7] Systems Biology and Translational Medicine
[8] TX
[9] TX.United States
[10] Temple
[11] United States
[12] University of Texas at Houston Medical School Houston
关键词
cAMP; Gastrointestinal hormones; Growth factors; Mitosis; Nerves;
D O I
暂无
中图分类号
R575.6 [胆囊疾病];
学科分类号
1002 ; 100201 ;
摘要
The objectives of this review are to outline the recent findings related to the morphological heterogeneity of the biliary epithelium and the heterogeneous pathophysiological responses of different sized bile ducts to liver gastrointestinal hormones and peptides and liver injury/toxins with changes in apoptotic, proliferative and secretory activities. The knowledge of biliary function is rapidly increasing because of the recognition that biliary epithelial cells (cholangiocytes) are the targets of human cholangiopathies, which are characterized by proliferation/damage of bile ducts within a small range of sizes. The unique anatomy, morphology, innervation and vascularization of the biliary epithelium are consistent with function of cholangiocytes within different regions of the biliary tree. The in vivo models [e.g., bile duct ligation (BDL), partial hepatectomy, feeding of bile acids, carbon tetrachloride (CCl4) orα-naphthylisothiocyanate (ANIT)] and the in vivo experimental tools [e.g., freshly isolated small and large cholangiocytes or intrahepatic bile duct units (IBDU) and primary cultures of small and large murine cholangiocytes] have allowed us to demonstrate the morphological and functional heterogeneity of the intrahepatic biliary epithelium. These models demonstrated the differential secretory activities and the heterogeneous apoptotic and proliferative responses of different sized ducts. Similar to animal models of cholangiocyte proliferation/injury restricted to specific sized ducts, in human liver diseases bile duct damage predominates specific sized bile ducts. Future studies related to the functional heterogeneity of the intrahepatic biliary epithelium may disclose new pathophysiological treatments for patients with cholangiopathies.
引用
收藏
页码:3523 / 3536
页数:14
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