T Cell Receptor Signaling Pathways:New Targets for Herpes Simplex Virus

被引：0

作者：

Youjia CAOYapeng LI Yingchi ZHANG and Cuizhu ZHANG Key Laboratory of Bioactive Materials of Ministry of EducationNankai UniversityTianjin ChinaTianjin Key Laboratory of Protein SciencesNankai UniversityTianjin ChinaDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin China ^{[1
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机构：

来源：

Virologica Sinica | 2008年 / 06期

关键词：

Herpes simplex virus; T cell receptor; Signaling;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Herpes simplex viruses (HSV-1 and HSV-2) cause global morbidity and synergistically correlate with HIV infection. HSV exists life-long in a latent form in sensory neurons with intermittent reactivation,in despite of host immune surveillance. While abundant evidence for HSV interfering with innate immune responses so as to favor the replication and propagation of the virus,several lines of evidence declare that HSV attenuates adaptive immunity by various mechanisms,including but not limited to the ablation of antigen presentation,induction of apoptosis,and interruption of cellular signaling. In this review,we will focus on the perturbative role of HSV in T cells signaling.

引用

页码：429 / 437

页数：9

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