Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer

被引：0

作者：

Daisuke Kyuno ^{[1
]}

Hiroshi Yamaguchi ^{[1
]}

Tatsuya Ito ^{[1
]}

Tsuyoshi Kono ^{[1
,2
]}

Yasutoshi Kimura ^{[1
]}

Masafumi Imamura ^{[1
]}

Takumi Konno ^{[2
]}

Koichi Hirata ^{[1
]}

Norimasa Sawada ^{[3
]}

Takashi Kojima ^{[2
]}

机构：

[1] Department of Surgery, Sapporo Medical University School of Medicine

[2] Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine

[3] Department of Pathology, Sapporo Medical University School of Medicine

来源：

World Journal of Gastroenterology | 2014年 / 31期

关键词：

Tight junctions; Claudins; Tricellulin; MarvelD3; Normal human pancreatic duct epithelial cells; Pancreatic cancer; Protein kinase C; Epithelial to mesenchymal transition;

D O I：

暂无

中图分类号：

R735.9 [胰腺肿瘤];

学科分类号：

100214 ;

摘要：

Pancreatic cancer continues to be a leading cause of cancer-related death worldwide and there is an urgent need to develop novel diagnostic and therapeutic strategies to reduce the mortality of patients with this disease. In pancreatic cancer, some tight junction proteins, including claudins, are abnormally regulated and therefore are promising molecular targets for diagnosis, prognosis and therapy. Claudin-4 and-18 are overexpressed in human pancreatic cancer and its precursor lesions. Claudin-4 is a high affinity receptor of Clostridium perfringens enterotoxin(CPE). The cytotoxic effects of CPE and monoclonal antibodies against claudin-4 are useful as novel therapeutic tools for pancreatic cancer. Claudin-18 could be a putative marker and therapeutic target with prognostic implications for patients with pancreatic cancer. Claudin-1,-7, tricellulin and marvelD3 are involved in epithelial to mesenchymal transition(EMT) of pancreatic cancer cells and thus might be useful as biomarkers during disease. Protein kinase C is closely related to EMT of pancreatic cancer and regulates tight junctions of normal human pancreatic duct epithelial cells and the cancer cells. This review focuses on the regulation of tight junctions via protein kinase C during EMT in human pancreatic cancer for the purpose of developing new diagnostic and therapeutic modalities for pancreatic cancer.

引用

页码：10813 / 10824

页数：12

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