Glycation of high-density lipoprotein in type 2 diabetes mellitus

被引：0

作者：

SUN Jiateng ^{[1
]}

SHEN Ying ^{[2
]}

L Ankang ^{[1
]}

LU Lin ^{[1
]}

SHEN Weifeng ^{[1
]}

机构：

[1] Department of Cardiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine

[2] Institute of Cardiovascular Diseases,Shanghai Jiao Tong University,School of Medicine

来源：

中华医学杂志（英文版） | 2013年 / 126卷 / 21期

关键词：

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To evaluate whether glycation of high-density lipoprotein(HDL)increases cardiovascular risk in patients with type 2 diabetes mellitus by altering its anti-atherogenic property.Data sources Data cited in this review were obtained mainly from Pubmed and Medline in English from 2000 to 2013,with keywords"glycation","HDL",and"atherosclerosis".Study selection Articles regarding glycation of HDL and its role in atherogenesis in both humans and experimental animal models were identified,retrieved and reviewed.Results Glycation alters the structure of HDL and its associated enzymes,resulting in an impairment of atheroprotective functionality and increased risks for cardiovascular events in type 2 diabetic patients.Conclusion Glycation of HDL exerts a deleterious effect on the development of cardiovascular complications in diabetes.

引用

页码：4162 / 4165