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Increased Expression of Intercellular Adhesion Molecule-1,Vascular Cellular Adhesion Molecule-1 and Leukocyte Common Antigen in Diabetic Rat Retina
被引：0
|作者：
Ningyan Bai Shibo Tang Jing Ma Yan Luo Shaofeng Lin Zhongshan Ophthalmic Center Sun Yatsen University Guangzhou China
[510060
]
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关键词：
diabetic retinopathy;
leukocyte;
adhesion molecules;
rat;
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中图分类号：
R774.1 [视网膜疾病];
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摘要：
<正> Purpose: To understand the expression and distribution of intercellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1(VCAM-1)and CD45 (Leukocyte Common Antigen) in the control nondiabetic and various courses of diabetic rats retina. To explore the role of adhesion molecules (AMs) and the adhesion of leukocytes to vascular endothelial cells via AMs in diabetic retinopathy(DR).Methods: Sixty healthy adult male Wistar rats were randomly divided into diabetic groups (induced by Streptozotocin, STZ) and normal control groups. Rats in these two groups were further randomly divided into 3, 7, 14, 30, 90 and 180 days-group, including 5 rats respectively. The immunohistochemical studies of ICAM-1, VCAM-1 and CD45 were carried out in the retinal digest preparations or retinal paraffin sections, and the results were analyzed qualitatively, semi-quantitatively.Results: No positive reaction of VCAM-1 was found, and weak reactions of ICAM-1, CD45 were found in nondiabetic rats retina. The differ
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页码：176 / 183
页数：8
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