疲劳的动物模型及发生机制研究进展

被引:12
|
作者
王智 [1 ]
闫明珠 [1 ]
夏天吉 [1 ]
刘新民 [1 ]
潘瑞乐 [1 ]
周云丰 [1 ]
陶雪 [1 ]
常琪 [1 ]
机构
[1] 中国医学科学院/北京协和医学院药用植物研究所
基金
国家重点研发计划;
关键词
疲劳; 动物模型; 行为学; 疲劳机制;
D O I
暂无
中图分类号
R442.9 [其他]; R-332 [医用实验动物学];
学科分类号
1001 ; 100208 ;
摘要
如今,疲劳广泛存在于各类人群中,这与人们的生活方式以及紧张繁重的工作状态密切相关。疲劳因其发生原因多且对机体的影响相对主观,故并未受到人们的广泛关注和重视。在目前的药物或保健品抗疲劳功效研究中,已报道的疲劳动物模型有包括采用物理、化学、免疫和炎症、放射线、手术、基因工程和癌因等单一因素或多种因素所诱导构建的多种模型。并且人们对疲劳的发生机制提出了一系列学说,包括能量耗竭学说、代谢产物堆积学说、内环境稳态失调学说、自由基影响理论和中枢神经系统保护性抑制学说。本文就近20年来在抗疲劳药物和保健品研究中所涉及到的疲劳动物模型以及可能的发生机制进行了概况总结,为抗疲劳产品的功效评价和机制研究提供参考。
引用
收藏
页码:1937 / 1943
页数:7
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