PDE7A expression on alcohol consumption and alcohol withdrawal in striatum of C57BL/6J mice

被引：0

作者：

XU Bing-bing ^{[1
]}

ZHOU Yan-meng ^{[1
]}

ZHANG Han-ting ^{[1
,2
]}

机构：

[1] Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Sciences

[2] Departments of Neuroscience and Behavioral Medicine & Psychiatry, The Rockefeller Neuroscience Institute, West Virginia University Health Sciences Center

来源：

中国药理学与毒理学杂志 | 2019年 / 10期

关键词：

phosphodiesterase-7A; alcohol consumption; alcohol withdrawal; mice;

D O I：

暂无

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

OBJECTIVE To observe PDE7A expression on alcohol consumption and alcohol withdrawal in the striatum of C57BL/6J mice. METHODS Forty adult female C57BL/6J mice were randomly divided into 3 groups: water intake control, alcohol（10% v/v） drinking(18 h · d;for 7 d), and alcohol withdrawal（for 24 h）.PDE7A expression was analyzed using Western blotting in striatal tissues from mice. RESULTS Compared to the control, alcohol drinking mice displayed increases in the expression of PDE7A in the striatum, which decreased to normal 24 h after withdrawal. CONCLUSION The results suggest that PDE7, in particular PDE7A, may play a unique role in the regulation of ethanol depdendence.

引用

页码：851 / 852

页数：2