卵巢癌组织中泛素1的表达变化及其临床意义

被引：6

作者：

王静 ^{[1
]}

贺英 ^{[1
]}

王萍 ^{[1
]}

武欣 ^{[2
]}

机构：

[1] 河北北方学院附属第一医院

[2] 河北北方学院病理教研室

来源：

山东医药 | 2018年 / 58卷 / 35期

关键词：

泛素样蛋白; 泛素1; 卵巢肿瘤; 卵巢癌;

D O I：

暂无

中图分类号：

R737.31 [卵巢肿瘤];

学科分类号：

100214 ;

摘要：

目的观察卵巢癌组织中泛素1的表达变化,并探讨其临床意义。方法留取80例卵巢癌患者的卵巢癌组织和癌旁正常组织,采用免疫组化法检测泛素1,分析其表达水平与卵巢癌患者临床病理参数的关系及与卵巢癌预后的相关性,建立Cox回归模型分析影响卵巢癌预后的因素。结果泛素1在卵巢癌组织中的阳性表达率为72.50%(58/80)、癌旁正常组织为17.50%(14/80),两者相比,P<0.01。卵巢癌组织泛素1的阳性表达与肿瘤的分化程度、FIGO分期、淋巴结转移、CA125(+)、HE4(+)、Ki-67表达有关(P均<0.05)。泛素1阳性表达的卵巢癌患者较阴性表达患者生存期长(P<0.05)。泛素1是卵巢癌预后的独立影响因素。结论泛素1在卵巢癌组织中的表达水平较高,与卵巢癌的临床病理特征及预后关系密切,可作为卵巢癌诊断和预后预测的潜在生物学指标。

引用

页码：61 / 63

页数：3

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