辅助性T细胞可塑性及其分化的调控机制

被引：1

作者：

余思菲

吴长有

机构：

[1] 中山大学医学院免疫研究所热带传染病教育部重点实验室

来源：

生命科学 | 2016年 / 28卷 / 02期

关键词：

T辅助细胞; 可塑性; 分化;

D O I：

10.13376/j.cbls/2016023

中图分类号：

R392.12 [免疫细胞生物学];

学科分类号：

摘要：

辅助性CD4+T细胞是适应性免疫应答的主要淋巴细胞。继人们首次在小鼠体内发现并命名Th1和Th2后,近20多年来又陆续发现了其他功能的Th细胞亚群,包括Th9、Th17、Th22、Tfh和Treg细胞等。关于新型Th细胞亚群的表型特征、免疫学功能和分化机制的研究成为近几年的热点,特别是Th细胞可塑性概念的提出,使得Th细胞的多功能性、相互作用和分化调控机制更加复杂化。现将总结分析国内外关于Th9、Th17、Tfh和Th22细胞的最新研究成果,论述辅助性T细胞的功能、分化的可塑性及其机制。

引用

页码：162 / 169

页数：8

共 20 条

[1] Increased IL-21 expression in chronic rhinosinusitis with nasalpolyps
Xiao, L.
Wei, Y.
Zhang, Y. -N.
Luo, X.
Yang, B. -Y.
Yu, S. -F.
Wu, X. -M.
Wu, C. -Y.
Li, H. -B.
[J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2015, 45 (02): : 404 - 413
[2] Th9 cells, new players in adaptive immunity[J] . Edgar Schmitt,Matthias Klein,Tobias Bopp.Trends in Immunology . 2013
[3] Th9 cells: differentiation and disease[J] . Mark H. Kaplan.Immunol Rev . 2013 (1)
[4] Th9 cells promote antitumor immune responses in vivo
Lu, Yong
Hong, Sungyoul
Li, Haiyan
Park, Jungsun
Hong, Bangxing
Wang, Lijuan
Zheng, Yuhuan
Liu, Zhiqiang
Xu, Jingda
He, Jin
Yang, Jing
Qian, Jianfei
Yi, Qing
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (11): : 4160 - 4171
[5] Activin A and TGF-β promote T H 9 cell–mediated pulmonary allergic pathology[J] . Carla P. Jones,Lisa G. Gregory,Benjamin Causton,Gaynor A. Campbell,Clare M. Lloyd.The Journal of Allergy and Clinical Immunology . 2012 (4)
[6] Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition
Nakayamada, Shingo
Kanno, Yuka
Takahashi, Hayato
Jankovic, Dragana
Lu, Kristina T.
Johnson, Thomas A.
Sun, Hong-wei
Vahedi, Golnaz
Hakim, Ofir
Handon, Robin
Schwartzberg, Pamela L.
Hager, Gordon L.
O'Shea, John J.
[J]. IMMUNITY, 2011, 35 (06) : 919 - 931
[7] Follicular Helper CD4 T Cells (TFH)[J] . Shane Crotty.Annual Review of Immunology . 2011
[8] Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease[J] . Wenjun Ouyang,Sascha Rutz,Natasha K. Crellin,Patricia A. Valdez,Sarah G. Hymowitz.Annual Review of Immunology . 2011
[9] Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells
Staudt, Valerie
Bothur, Evita
Klein, Matthias
Lingnau, Karen
Reuter, Sebastian
Grebe, Nadine
Gerlitzki, Bastian
Hoffmann, Markus
Ulges, Alexander
Taube, Christian
Dehzad, Nina
Becker, Marc
Stassen, Michael
Steinborn, Andrea
Lohoff, Michael
Schild, Hansjoerg
Schmitt, Edgar
Bopp, Tobias
[J]. IMMUNITY, 2010, 33 (02) : 192 - 202
[10] Differentiation of Effector CD4 T Cell Populations *[J] . Jinfang Zhu,Hidehiro Yamane,William E. Paul.Annual Review of Immunology . 2010 (1)

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